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논문 기본 정보

자료유형
학술저널
저자정보
김재원 (을지대학병원) 이혜림 (을지대학병원) 박주승 (을지대학병원) 김지훈 (을지대학병원) 유건희 (을지대학교병원)
저널정보
대한마취통증의학회(구 대한마취과학회) Anesthesia and Pain Medicine Anesthesia and Pain Medicine Vol.13 No.1
발행연도
2018.1
수록면
23 - 29 (7page)

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Background: This study evaluated the effects of pre-anesthetic administration of dexmedetomidine on sedative, cardiovascular, and recovery parameters. Methods: This was a prospective, randomized, double-blind, placebo-controlled study. We selected 60 patients who were scheduled to undergo laparoscopic cholecystectomy. They were randomly divided into two groups and received 0.5 mg/kg of dexmedetomidine (group D) or normal saline (group S) over 10 minutes before induction of anesthesia. The Ramsay sedation scale (RSS) score and bispectral index (BIS) were recorded after completion of the dexmedetomidine infusion. Mean arterial pressure (MAP), heart rate (HR), peripheral pulse oximetry, cardiac output (CO), and systemic vascular resistance (SVR) were recorded. The modified Aldrete recovery score (MARS) was recorded in the recovery room. Results: After completion of the dexmedetomidine infusion, BIS reduction was less than 20% (97.1 ± 2.4, 83.8 ± 4.8; P < 0.001), but RSS-rated sedation was appropriate (P < 0.001). HR was lowest at the end of the dexmedetomidine infusion and there was a significant difference between groups (P < 0.001); however, MAP was not significantly different between groups (P = 0.139). CO was lowest and SVR was highest at the end of the dexmedetomidine infusion. There was no significant difference in MARS values between groups (P = 0.190). Conclusions: A pre-anesthetic dexmedetomidine (0.5 mg/kg) provided appropriate sedation without serious changes in cardiovascular parameters or a prolonged recovery time.

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