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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 998 - 1,005 (8page)
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Purpose: Intranasal dexmedetomidine is an effective sedative for premedication and is regularly used to reduce preoperative tension and anxiety in children. This study aimed to assess the effect of intranasally adjunctive dexmedetomidine on perioperativesedative and analgesic requirements in adults.
Materials and Methods: Patients were randomly divided into four groups to receive preoperative administration of saline, intranasaldexmedetomidine 1 μg/kg and 2 μg/kg, and intravenous dexmedetomidine 1 μg/kg, respectively. Propofol and remifentanil were target-controlled infused to maintain intraoperative bispectral index at 45–55 and blood pressure at baseline value±20%. Sufentanil was administered to maintain postoperative visual analogue scale ≤3. Perioperative anesthetics requirements were compared using nonparametric tests.
Results: Intranasal dexmedetomidine significantly attenuated propofol requirements for anesthesia induction and maintenance in a dose-dependent manner. Patients given intranasal dexmedetomidine 2 μg/kg required less remifentanil for anesthesia maintenance.
The first postoperative request for sufentanil analgesia was delayed in patients given intranasal dexmedetomidine 2 μg/kg. The anesthetics-sparing effect of intranasal dexmedetomidine was significantly weaker than intravenous dexmedetomidine at the same dose of 1 μg/kg. The incidences of adverse events, including hemodynamic instability and delayed recovery, were comparablewith and without intranasal dexmedetomidine.
Conclusion: Intranasal administration of dexmedetomidine can reduce perioperative anesthetic requirements, and a dose of dexmedetomidine 2 μg/kg produces a better effect in adults. The anesthetics-sparing effect of intranasal dexmedetomidine 1 μg/kg is less than that with the same intravenous dose of dexmedetomidine.
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참고문헌 (29)
참고문헌 신청
Kaur M / 2011 / Current role of dexmedetomidine in clinical anesthesia and intensive care / Anesth Essays Res 5:128~133
Arcangeli A / 2009 / Dexmedetomidine use in general anaesthesia / Curr Drug Targets 10:687~695
Grassin-Delyle S / 2012 / Intranasal drug delivery: an effcient and noninvasive route for systemic administration: focus on opioids / Pharmacol Ther 134:366~379
Jia JE / 2013 / A randomised study of intranasal dexmedetomidine and oral ketamine for premedication in children / Anaesthesia 68:944~949
Ghali AM / 2011 / Preanesthetic medication in children: a comparison of intranasal dexmedetomidine versus oral midazolam / Saudi J Anaesth 5:387~391
Arcangeli A / 2009 / Dexmedetomidine use in general anaesthesia / Curr Drug Targets 10:687~695
Grassin-Delyle S / 2012 / Intranasal drug delivery: an effcient and noninvasive route for systemic administration: focus on opioids / Pharmacol Ther 134:366~379
Jia JE / 2013 / A randomised study of intranasal dexmedetomidine and oral ketamine for premedication in children / Anaesthesia 68:944~949
Ghali AM / 2011 / Preanesthetic medication in children: a comparison of intranasal dexmedetomidine versus oral midazolam / Saudi J Anaesth 5:387~391
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