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자료유형
학술저널
저자정보
안지현 (대구파티마병원 마취통증의학과) 윤덕근 (대구파티마병원 마취통증의학과) 반종석 (대구 파티마병원 마취통증의학과) 이상곤 (대구 파티마병원 마취통증의학과) 이지향 (대구 파티마병원 마취통증의학과) 김은주 (대구파티마병원 마취통증의학과)
저널정보
대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.69 No.5
발행연도
2016.1
수록면
446 - 452 (7page)

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Background: Dexmedetomidine is a useful sedative agent for spinal anesthesia. However, it has been reported that dexmedetomidine decreases heart rate in a dose-dependent manner. In the current study, we compared the administration of a bolus dose of midazolam and bolus loading of dexmedetomidine over 10 min with the goal of identifying an additional method of sedation. Methods: Ninety patients classified as American Society of Anesthesiologists physical status I–II who were undergoing spinal anesthesia were divided into two groups. In the midazolam and dexmedetomidine combined group (group MD), 10 min after bolus loading of 0.05 mg/kg midazolam, 0.5 μg/kg/h dexmedetomidine was continuously infused. In the dexmedetomidine group (group D), 1 μg/kg dexmedetomidine was infused over 10 min, and then 0.5 μg/kg/h dexmedetomidine was continuously infused. Results: At 10 min, the sedation depth of the two groups was almost equal. In both groups, the bispectral index was within the optimal score range of 55–80 and the Ramsay Sedation Scale score was within the optimal range of 3–5. Satisfaction with sedation for both patient and surgeon did not differ between the two groups. At 10 min, heart rate was significantly lower (P < 0.010) in group D and mean blood pressure was significantly lower (P < 0.010) in group MD. The prevalence of bradycardia, hypotension, and hypoxia did not differ statistically between the two groups (P = 0.714, P = 0.089, P = 0.495, respectively). Conclusions: Midazolam bolus and dexmedetomidine continuou

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