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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 239 - 247 (9page)
이용수
초록· 키워드
오류제보하기
Background: Extracorporeal membrane oxygenation (ECMO) is a lifesaving therapy used in critically ill patients with severe cardiopulmonary dysfunction. Continuous renal replacement therapy (CRRT) is supplemented to treat fluid overload, acute kidney injury, and electrolyte disturbances during ECMO. However, the best time to initiate CRRT is not well-defined. We performed this study to identify the optimal timing of CRRT for ECMO. Methods: We conducted a multicenter retrospective cohort study of 296 patients over 12 years. Patients received CRRT during ECMO at Seoul National University Hospital, Seoul National University Bundang Hospital, or Yonsei University Hospital. We assigned patients to an early or late CRRT group depending on the CRRT initiation time. We considered early CRRT to be CRRT instituted within 72 hours of ECMO initiation. Results: Among 296 patients, 212 patients (71.6%) received early CRRT. After using a propensity score matching method, 47 patients were included in each group. The time from ECMO initiation to CRRT initiation was 1.1 ± 0.9 days in the early CRRT group and 14.6 ± 18.6 days in the late CRRT group. No difference in patients’ mortality (P = 0.834) or hospital stay (P = 0.627) between the early and late CRRT groups was found. After adjusting all covariables, there was no significant difference in mortality between the early and late CRRT groups (hazard ratio, 0.697; 95% confidence interval, 0.410-1.184; P = 0.182). Conclusion: This study showed that early CRRT may not be superior to late CRRT in ECMO patients. Further clinical trials are warranted.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Hill JD / 1972 / Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure (shock-lung syndrome). Use of the Bramson membrane lung / N Engl J Med 286:629~634
Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators / 2009 / Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome / JAMA 302:1888~1895
Peek GJ / 2009 / Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial / Lancet 374:1351~1363
Noah MA / 2011 / Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1) / JAMA 306:1659~1668
이재준 / 2015 / Efficacy of Veno-Venous Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Failure / Yonsei Medical Journal 56(1):212~219
Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators / 2009 / Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome / JAMA 302:1888~1895
Peek GJ / 2009 / Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial / Lancet 374:1351~1363
Noah MA / 2011 / Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1) / JAMA 306:1659~1668
이재준 / 2015 / Efficacy of Veno-Venous Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Failure / Yonsei Medical Journal 56(1):212~219
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