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This study was to demonstrate the comparison of immunological activity between vegetable soup made by fresh and extruded radish in in-vitro (bone marrow-derived macrophages and dendritic cells, and mouse splenocytes) and invivo models. In cell survival tests, extruded radish added to vegetable soup (EVS) and non-extruded radish added to vegetable soup powder (NEVS) were treated with bone-marrow derived macrophages, dendritic cells, and mouse splenocytes, and showed no cytotoxic effect at a dose below 1000 μg/mL. EVS treated cells had greater cell proliferation and cytokine [tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, IL-2, interferon (INF)-γ] production when compared to the NEVS treated group. Cell surface marker (CD 80/86, MHC class I/II) expression in bone marrow-derived macrophages and dendritic cells was evenly increased in the EVS treated group. In in-vivo study, administration of EVS increased for the CD4 and CD8 T cell population in splenocyte and cytokine production (IL-2, IFN-γ, TNF-α) but not Th2 type cytokines (IL-4). Therefore, adding the extruded radish is a more effective method for vegetable soup to increase immunological activity against immune cells.
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참고문헌 (46)
참고문헌 신청
강보경 / 2014 / 참치(Katsuwonus pelamis) 자숙액 농축물의 마우스 대식세포 및 비장세포에 대한 면역증강활성 / 한국수산과학회지 47(6):776~786
Bendich A / 1994 / Recent advances in clinical research involving carotenoids / Pure Appl. Chem. 66:1017~1025
Byrd JC / 2000 / Dimerization of the insulin-like growth factor II/mannose 6-phosphate receptor / J. Biol. Chem. 25:18647~18656
변의홍 / 2015 / 참모자반 조다당 추출물과 에탄올 추출물의 대식세포 및 비장세포 활성 비교 / 한국식품영양과학회지 44(11):1621~1628
변의홍 / 2017 / 자소엽(Perilla frutescens Britton var. acuta Kudo) 조다당류 추출물의 면역활성 효과 / 한국식품과학회지 49(5):559~566
Bendich A / 1994 / Recent advances in clinical research involving carotenoids / Pure Appl. Chem. 66:1017~1025
Byrd JC / 2000 / Dimerization of the insulin-like growth factor II/mannose 6-phosphate receptor / J. Biol. Chem. 25:18647~18656
변의홍 / 2015 / 참모자반 조다당 추출물과 에탄올 추출물의 대식세포 및 비장세포 활성 비교 / 한국식품영양과학회지 44(11):1621~1628
변의홍 / 2017 / 자소엽(Perilla frutescens Britton var. acuta Kudo) 조다당류 추출물의 면역활성 효과 / 한국식품과학회지 49(5):559~566
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