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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: 15,16-dihydrotanshinone I (DHTS) is a natural abietane diterpenoid that is mainly found in the roots of Salvia miltiorrhiza Bunge (Labiatae). DHTS exhibits a potential anti-proliferative effect in various human cancer cells. However, the mechanisms of action of DHTS as an anti-cancer agent have not been fully elucidated. Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells. Methods: The anti-proliferative effects of DHTS were evaluated by the sulforhodamine B assay in SK-HEP-1 cells. Cell cycle distribution was analyzed by flow cytometry. The elucidation of mechanisms of action such as the AMPK/AKT/mTOR and mitogen-activated protein kinase (MAPK) pathway was assessed by Western blot analysis. Results: DHTS showed a significant anti-proliferative activity against SK-HEP-1 cells. DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21. DHTS also activated the AMPK signaling. In addition, DHTS downregulated the Akt/mTOR and MAPK signaling pathways. Conclusions: Our results suggest that the anti-proliferative activity of DHTS might be associated with the induction of G0/G1 phase cell cycle arrest and regulation of AMPK/Akt/mTOR and MAPK signaling pathways in SK-HEP-1 cells.
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참고문헌 (28)
참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Chan SL / 2012 / Targeted therapy of hepatocellular carcinoma: present and future / J Gastroenterol Hepatol 27:862~872
Llovet JM / 2013 / Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study / J Clin Oncol 31:3509~3516
Cheng AL / 2013 / Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial / J Clin Oncol 31:4067~4075
서상준 / 2013 / 간세포암에서 분자표적치료제의 현황 / 대한소화기학회지 61(3):136~146
Chan SL / 2012 / Targeted therapy of hepatocellular carcinoma: present and future / J Gastroenterol Hepatol 27:862~872
Llovet JM / 2013 / Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study / J Clin Oncol 31:3509~3516
Cheng AL / 2013 / Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial / J Clin Oncol 31:4067~4075
서상준 / 2013 / 간세포암에서 분자표적치료제의 현황 / 대한소화기학회지 61(3):136~146
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