지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.4
- 발행연도
- 2015.1
- 수록면
- 339 - 345 (7page)
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초록· 키워드
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Purpose: Although many previous studies have attempted to identify differences between atopic asthma (AA) and non-atopic asthma (NAA), they have mainly focused on the difference of each variable of lung function and airway inflammation. The aim of this study was to evaluate relationships between lung function, bronchial hyperresponsiveness (BHR), and the exhaled nitric oxide (eNO) levels in children with AA and NAA. Methods: One hundred and thirty six asthmatic children aged 5-15 years and 40 normal controls were recruited. Asthma cases were classified as AA (n=100) or NAA (n=36) from skin prick test results. Lung function, BHR to methacholine and adenosine-5’-monophosphate (AMP), eNO, blood eosinophils, and serum total IgE were measured. Results: The AA and NAA cases shared common features including a reduced small airway function and increased BHR to methacholine. However, children with AA showed higher BHR to AMP and eNO levels than those with NAA. When the relationships among these variables in the AA and NAA cases were evaluated, the AA group showed significant relationships between lung function, BHR to AMP or methacholine and eNO levels. However, the children in the NAA group showed an association between small airway function and BHR to methacholine only. Conclusions: These findings suggest that the pathogenesis of NAA may differ from that of AA during childhood in terms of the relationship between lung function, airway inflammation and BHR.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Agache I / 2012 / Untangling asthma phenotypes and endotypes / Allergy 67:835~846
Martinez FD / 1995 / Asthma and wheezing in the first six years of life. The Group Health Medical Associates / N Engl J Med 332:133~138
Stein RT / 1997 / Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood / Thorax 52:946~952
Illi S / 2006 / Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study / Lancet 368:763~770
Kelley CF / 2005 / Asthma phenotypes, risk factors, and measures of severity in a national sample of US children / Pediatrics 115:726~731
Martinez FD / 1995 / Asthma and wheezing in the first six years of life. The Group Health Medical Associates / N Engl J Med 332:133~138
Stein RT / 1997 / Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood / Thorax 52:946~952
Illi S / 2006 / Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study / Lancet 368:763~770
Kelley CF / 2005 / Asthma phenotypes, risk factors, and measures of severity in a national sample of US children / Pediatrics 115:726~731
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