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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 178 - 185 (8page)
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초록· 키워드
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In this study, the effect of complex hot water extracts of Cirsium jaonicum, Artemisia annua and Curcuma longa (CAC) on the improvement of non-alcoholic fatty liver disease (NAFLD) was investigated. CAC inhibited fatty acid synthesis and lipid accumulation in HepG2 cells cultured with free fatty acid (FFA). In the NAFLD animal model, CAC extract suppressed the increase in body weight, liver, and epididymis fat weight, and suppressed the increase in hepatocyte fat and blood triglyceride. In addition, by blocking the Nrf2/HO-1 signaling pathway, cells were protected from oxidative stress in hepatocytes. Moreover, CAC inhibited the expression of COX-2, iNOS, TNF-α and IL-17 in hepatocytes. These results suggest the possibility that CAC extract can be applied in the field of health functional foods and pharmaceuticals for improvement and prevention of NAFLD.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (26)
참고문헌 신청
Rinella, M. E. / 2015 / Nonalcoholic fatty liver disease : a systematic review / Jama 313:2263~2273
Younossi, Z. / 2018 / Global burden of NAFLD and NASH : trends, predictions, risk factors and prevention / Nature Reviews Gastroenterology &Hepatology 15:11~20
Reynoso, E. / 2012 / NAFLD: The role of exercise in treating NAFLD. Nature Reviews / Gastroenterology & Hepatology 9:368~370
Cohen, J. C. / 2011 / Human fatty liver disease: old questions and new insights / Science (New York, N.Y.) 332:1519~1523
Harley, I. T. / 2014 / IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice / Hepatology (Baltimore, Md.) 59:1830~1839
Younossi, Z. / 2018 / Global burden of NAFLD and NASH : trends, predictions, risk factors and prevention / Nature Reviews Gastroenterology &Hepatology 15:11~20
Reynoso, E. / 2012 / NAFLD: The role of exercise in treating NAFLD. Nature Reviews / Gastroenterology & Hepatology 9:368~370
Cohen, J. C. / 2011 / Human fatty liver disease: old questions and new insights / Science (New York, N.Y.) 332:1519~1523
Harley, I. T. / 2014 / IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice / Hepatology (Baltimore, Md.) 59:1830~1839
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