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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 11 (11page)
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Background: Recent studies have indicated the significant association between non-alcoholic fatty liver disease (NAFLD) and depression. However, there is ongoing debate on whether the risk for depression is actually related with the presence and severity of NAFLD. Thus, this study was conducted to investigate the association between depression and NAFLD evaluated by diverse modalities. Methods: A total of 112,797 participants from the Korean general population were enrolled. The study participants were categorized into three groups according to degree of NAFLD evaluated by ultrasonography, fatty liver index (FLI) and fibrosis-4 score (FIB-4). Depression was defined as a score of Center for Epidemiological Studies-Depression (CES-D) ≥ 16, and the odd ratios (ORs) and 95% confidence interval (CI) for depression (adjusted ORs [95% CI]) were assessed by multiple logistic regression analyses. Results: In the unadjusted model, the presence and severity of NAFLD was not significantly associated with depressive symptoms. However, in the fully adjusted model, ORs for depression increased in proportion to the degree of ultrasonographically detected NAFLD (mild fatty liver: 1.14 [1.06–1.22]; and moderate to severe fatty liver: 1.32 [1.17–1.48]). An association was also observed between depression and FLI (30 ≤ FLI < 60: 1.06 [0.98–1.15]; FLI ≥ 60: 1.15 [1.02–1.29]). Conclusion: The presence and severity of NAFLD is significantly associated with depressive symptoms. In addition, this association was more distinct after adjusting for covariates including age, gender and insulin resistance. This finding indicates the necessity of further study evaluating the incidental relationship of depression with NAFLD.
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참고문헌 (31)
참고문헌 신청
Spijker J / 2004 / Functional disability and depression in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS) / Acta Psychiatr Scand 110(3):208~214
Ustün TB / 2004 / Global burden of depressive disorders in the year 2000 / Br J Psychiatry 184(5):386~392
Andrade L / 2003 / The epidemiology of major depressive episodes : results from the International Consortium of Psychiatric Epidemiology(ICPE)Surveys / Int J Methods Psychiatr Res 12(1):3~21
Kessler RC / 2003 / The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) / JAMA 289(23):3095~3105
Murphy JM / 2000 / A 40-year perspective on the prevalence of depression : the Stirling County Study / Arch Gen Psychiatry 57(3):209~215
Ustün TB / 2004 / Global burden of depressive disorders in the year 2000 / Br J Psychiatry 184(5):386~392
Andrade L / 2003 / The epidemiology of major depressive episodes : results from the International Consortium of Psychiatric Epidemiology(ICPE)Surveys / Int J Methods Psychiatr Res 12(1):3~21
Kessler RC / 2003 / The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) / JAMA 289(23):3095~3105
Murphy JM / 2000 / A 40-year perspective on the prevalence of depression : the Stirling County Study / Arch Gen Psychiatry 57(3):209~215
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