Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea

이현주; Chang Jae Seung; Ahn Jhii Hyun; Kim Moon Young; Park Kyu-Sang; 안연순; Koh Sang Baek

doi:10.3961/jpmph.21.387

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자료유형: 학술저널

저자정보: 이현주 (연세대학교(원주의대)) Chang Jae Seung (Department of Physiology Yonsei University Wonju College of Medicine Wonju Korea) Ahn Jhii Hyun (Wonju Severance Christian Hospital Yonsei University Wonju College of Medicine Wonju Korea) Kim Moon Young (Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea) Park Kyu-Sang (Department of Physiology Yonsei University Wonju College of Medicine Wonju Korea) 안연순 (Department of Preventive Medicine Yonsei University Wonju College of Medicine Wonju Korea.) Koh Sang Baek (Department of Preventive Medicine Wonju College of Medicine Yonsei University Wonju Korea.)

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제54권 제6호

발행연도: 2021.11

수록면: 412 - 421 (10page)

DOI: 10.3961/jpmph.21.387

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Objectives: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent metabolic disease. Muscle is known to influence NAFLD development. Therefore, this study aimed to determine the relationships among low muscle mass, NAFLD, and hepatic fibrosis using various definitions of low muscle mass and NAFLD diagnostic methods, including magnetic resonance imaging-based proton density fat fraction (MRI-PDFF).Methods: This cross-sectional study included 320 participants (107 males, 213 females) from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population cohort. Muscle mass was assessed using whole-body dual-energy X-ray absorptiometry and adjusted for the height squared, body weight, and body mass index (BMI). NAFLD was diagnosed using ultrasonography (US), MRI-PDFF, and the comprehensive NAFLD score (CNS). Hepatic fibrosis was assessed using magnetic resonance elastography. Multivariable logistic and linear regression analyses were performed to determine the aforementioned associations.Results: According to US, 183 participants (57.2%) had NAFLD. Muscle mass adjusted for body weight was associated with NAFLD diagnosed using US (odds ratio [OR], 3.00; 95% confidence interval [CI], 1.70 to 5.31), MRI-PDFF (OR, 2.00; 95% CI, 1.13 to 3.53), and CNS (OR, 3.39; 95% CI, 1.73 to 6.65) and hepatic fibrosis (males: β=-0.070, p<0.01; females: β=-0.037, p<0.04). Muscle mass adjusted for BMI was associated with NAFLD diagnosed by US (OR, 1.71; 95% CI, 1.02 to 2.86) and CNS (OR, 1.95; 95% CI, 1.04 to 3.65), whereas muscle mass adjusted for height was not associated with NAFLD.Conclusions: Low muscle mass was associated with NAFLD and liver fibrosis; therefore, maintaining sufficient muscle mass is important to prevent NAFLD. A prospective study and additional consideration of muscle quality are needed to strengthen the findings regarding this association.

#Non-alcoholic fatty liver disease #Sarcopenia #Liver cirrhosis #Fibrosis

참고문헌 (32)

참고문헌 신청

Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association / Hepatology 55(6):2005~2023

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Im HJ / 2021 / Systematic review on the prevalence of nonalcoholic fatty liver disease in South Korea / Clin Res Hepatol Gastroenterol 45(4):101526

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Shafiee G / 2017 / Prevalence of sarcopenia in the world : a systematic review and meta-analysis of general population studies / J Diabetes Metab Disord 16:21

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