지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.49 No.1
- 발행연도
- 2022.3
- 수록면
- 137 - 149 (13page)
이용수
초록· 키워드
오류제보하기
We investigated the effects of Cirsium japonicum var. maackii (CJM) against oxidative stressinduced C6 glial cells and cognitive impairment in mice. To evaluate the anti-oxidative effect of the extract and fractions from CJM, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), and nitric oxide (NO) assays were conducted in H₂O₂-treated C6 glial cells. Furthermore, we identified the protective mechanisms of CJM with a scopolamine-treated mice model. The results revealed that H₂O₂ decreased the cell viability in C6 glial cells, indicating that H₂O₂ induced oxidative stress in glial cells. However, CJM fractions significantly increased cell viability in H₂O₂-treated C6 glial cells, which suggested that CJM protected against oxidative stress. CJM extract and fractions also reduced ROS and NO production, which were increased by H₂O₂ in C6 glial cells. In particular, the EtOAc fraction from CJM (EACJM) effectively protected against oxidative stress by increasing the cell viability and decreasing ROS and NO. Therefore, we carried out further in vivo experiments with EACJM. Scopolamine caused increases of ROS, thiobarbituric acid reactive substances (TBARS), and NO production. However, EACJM effectively alleviated ROS, TBARS, and NO levels compared to scopolamine-injected mice. In addition, EACJM up-regulated protein expressions of superoxide dismutase and glutathione peroxidase, indicating that EACJM enhanced the antioxidative system. Our results demonstrated that CJM had protective effects against oxidative stress in glial cells and memory dysfunction in mice. Based on these results, we propose that CJM could be a potential AD preventive and therapeutic agent.
목차
Abstract
Introduction
Materials and Methods
Results and Discussions
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protective effect of Cirsium japonicum var. maackii against oxidative stress in C6 glial cells
Korean Journal of Agricultural Science
2018 .09
-
Cirsium japonicum var. maackii inhibits hydrogen peroxide-induced oxidative stress in SH-SY5Y cells
Korean Journal of Agricultural Science
2021 .03
-
Protective effects of Cirsium japonicum var. maackii against amyloid beta-induced neurotoxicity in C6 glial cells
Korean Journal of Agricultural Science
2019 .06
-
Protective Role of Kimchi under Different Fermentation Stages from Oxidative Stress in C6 Glial Cell
한국식품영양과학회 학술대회발표집
2018 .10
-
Neuroprotective Effects of Flower from Cirsium japonicum var. maackii against H₂O₂-induced C6 Glial Cells
한국식품영양과학회 학술대회발표집
2024 .10
-
Simultaneous determination of methoxyflavones in selected Korean thistles
Journal of applied biological chemistry
2018 .01
-
H₂O₂로 유도된 C6 신경교세포의 세포사멸에 대한 감초 추출물과 감초 활성물질의 보호효과
한국약용작물학회지
2017 .10
-
Free radical scavenging activity of Cirsium japonicum var. maackii flower
Korean Journal of Agricultural Science
2023 .03
-
Anti-inflammatory effect of Mulberry vinegar against lipopolysaccharide and interferon gamma in C6 glial cells
한국식품영양과학회 학술대회발표집
2021 .10
-
Effect of Donganme (Sorghum bicolor L. Moench) against oxidative stress in vitro and in a cellular system in glial cells
Korean Journal of Agricultural Science
2020 .09
-
Antioxidant effect of Moringa ethanol extract and protective effect against oxidative stress induced by hydrogen peroxide in SH-SY5Y cells
한국식품영양과학회 학술대회발표집
2021 .10
-
Effects of fermented F3570 on Scopolamine-Induced Memory Deficits in Mice
한국식품영양과학회 학술대회발표집
2016 .10
-
선복화 에탄올 추출물의 Nitric Oxide 생성, 산화스트레스 및 대장암 세포 억제효과
한국약용작물학회지
2018 .02
-
노루오줌 에탄올 추출물의 산화스트레스 및 대장암 세포 억제활성
한국약용작물학회지
2018 .04
-
우산고로쇠의 항산화 및 신경세포에서의 산화적 스트레스 개선 효과
Journal of applied biological chemistry
2017 .01
-
Immunostimulatory Activity of Cirsium japonicum var. maackii Derived-Natural Substances in RAW 264.7 Mouse Macrophages
한국식품영양과학회 학술대회발표집
2023 .10
-
Protective Effect of Extracts of Glycine soja against Oxidative Damage in C2C12 Myoblasts
한국식품영양과학회 학술대회발표집
2021 .10
-
Protein Hydrolysate of Silkworm Pupa Prevents Memory Impairment Induced by Oxidative Stress in Scopolamine-Induced Mice via Modulating the Cholinergic Nervous System and Antioxidant Defense System
Preventive Nutrition and Food Science
2020 .12
-
Preventive Effect of Fermented Soybean Peptides digested by Protease from Aspegillus Oryzae on Oxidative Stress-Induced C2C12 myoblasts
한국식품영양과학회 학술대회발표집
2021 .10
-
Spirulina maxima Extract Ameliorate Oxidative Stress and Inflammatory Response in LPS-treated Human and Mouse Macrophage Cell.
한국식품영양과학회 학술대회발표집
2017 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0