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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.46 No.2
- 발행연도
- 2019.6
- 수록면
- 369 - 379 (11page)
이용수
초록· 키워드
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Alzheimer’s disease (AD) is the most common neurodegenerative disease associated with age, and amyloid beta (Aβ) is known to cause Alzheimer’s disease. In the present study, we investigated the protective effects of Cirsium japonicum var. maackii extract and its fractions against Aβ-induced neurotoxicity in C6 glial cells. The cells treated with Aβ<SUB>25-35</SUB> showed a decrease in cell viability and an increase in reactive oxygen species (ROS) production compared with the non-treated cells. However, the cells treated with the C. japonicum var. maackii extract and its fractions increased the cell viability and inhibited the Aβ-induced ROS production. These results demonstrate the neuroprotective effects of C. japonicum var. maackii against Aβ. To further examine the protective mechanism, we measured inflammation and apoptosis related protein expressions. The cells treated with extract and fractions from C. japonicum var. maackii down-regulated inflammatory related proteins such as cyclooxygenase-2, interleukin (IL)-1β, and IL-6, and attenuated apoptosis related proteins including B-cell lymphoma-2 (Bcl-2) associated X protein/Bcl-2 ratio. In particular, the ethanol and ethylacetate fraction exhibited higher inhibitory effect against ROS production and apoptosis-related protein expressions among the extract and the other fractions. Therefore, this study demonstrated the protective effects of C. japonicum var. maackii extract and its fractions against Aβ-induced neurotoxicity in C6 glial cells through the regulation of oxidative stress, inflammation, and apoptosis, suggesting that it might have potential as a therapeutic for AD.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (40)
참고문헌 신청
Ali T / 2017 / Anthocyanin-loaded PEG-gold nanoparticles enhanced the neuroprotection of anthocyanins in an Aβ1-42 mouse model of Alzheimer's disease / Molecular Neurobiology 54:6490~6506
Apelt J / 2001 / Beta-amyloid-induced glial expression of both pro-and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology / Brain Research 894:21~30
Block ML / 2005 / Microglia and inflammation-mediated neurodegeneration : Multiple triggers with a common mechanism / Progress Neurobiology 76:77~98
Butterfield DA / 2013 / Amyloid β-peptide(1-42)-induced oxidative stress in Alzheimer disease : Importance in disease pathogenesis and progression / Antioxidants & Redox Signaling 19:823~835
Canevari L / 2004 / Toxicity of amyloid beta peptide : Tales of calcium, mitochondria, and oxidative stress / Neurochemical Research 29:637~650
Apelt J / 2001 / Beta-amyloid-induced glial expression of both pro-and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology / Brain Research 894:21~30
Block ML / 2005 / Microglia and inflammation-mediated neurodegeneration : Multiple triggers with a common mechanism / Progress Neurobiology 76:77~98
Butterfield DA / 2013 / Amyloid β-peptide(1-42)-induced oxidative stress in Alzheimer disease : Importance in disease pathogenesis and progression / Antioxidants & Redox Signaling 19:823~835
Canevari L / 2004 / Toxicity of amyloid beta peptide : Tales of calcium, mitochondria, and oxidative stress / Neurochemical Research 29:637~650
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UCI(KEPA) : I410-ECN-0101-2019-520-000726190