지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제52권 제4호
- 발행연도
- 2022.7
- 수록면
- 443 - 451 (9page)
- DOI
- 10.1007/s40005-022-00567-x
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초록· 키워드
오류제보하기
Purpose More than half of hypertensive patients receive combination therapy with two or more drugs. For combination therapy with antihypertensive drugs, it is recommended to use complementary drugs with different mechanisms. In this study, the effects of combination therapy with telmisartan (an angiotensin II receptor type 1 blocker) and ramipril (an angiotensinconverting enzyme inhibitor) on blood pressure control and cardiovascular protection were verified.
Methods The systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate of spontaneously hypertensive rats (SHRs) were measured using a telemetry system. The protective effect of the drug combination against cardiovascular injury was determined by examining ligation-induced myocardial ischemia/reperfusion in SHRs and cuff-induced neointimal formation in C57BL/6 mice.
Results The combination therapy with telmisartan and ramipril significantly decreased SBP and MAP. In addition, the combination therapy significantly increased the expression of endothelial nitric oxide synthase and inhibited the proliferation of vascular smooth muscle cells by inhibiting DNA synthesis at the cuff-induced vascular injury site.
Conclusion The results of this study suggest that combination therapy with telmisartan and ramipril is an effective strategy for the treatment of hypertension and complications of hypertensive disorders.
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