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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 916 - 924 (9page)
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초록· 키워드
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MicroRNAs are widely involved in the pathogenesis of cardiovascular diseases through regulating gene expression via translational inhibition or degradation of their target mRNAs. Recent studies have indicated a critical role of microRNA-206 in myocardial ischaemia-reperfusion (I/R) injury. However, the function of miR-206 in myocardial I/R injury is currently un-clear. The present study was aimed to identify the specific role of miR-206 in myocardial I/R injury and explore the underlying molecular mechanism. Our results revealed that the expres-sion level of miR-206 was significantly decreased both in rat I/R group and H9c2 cells subjected to hypoxia/reoxygenation (H/R) compared with the corresponding control. Overexpression of miR-206 observably decreased infarct size and inhibited the cardiomyocyte apoptosis induced by I/R injury. Furthermore, bioinformatics analysis, luciferase activity and western blot assay proved that Gadd45beta (growth arrest DNA damage-inducible gene 45beta) was a direct target gene of miR-206. In addition, the expression of pro-apoptotic-related genes, such as p53, Bax and cleaved caspase3, was decreased in association with the down-regulation of Gadd45beta. In summary, this study demonstrates that miR-206 could protect against myocardial I/R injury by targeting Gadd45beta.
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참고문헌 (32)
참고문헌 신청
Baines, C. P. / 2011 / How and when do myocytes die during ischemia and reperfusion: the late phase / J. Cardiovasc. Pharmacol. Ther 16:239~243
Dai, Y. / 2016 / The role of microRNA-1 and microRNA-206 in the proliferation and differentiation of bovine skeletal muscle satellite cells / In vitro Cell. Dev. Biol. Animal 52:27~34
Edwards, M. G. / 2004 / Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice / Ann. N Y Acad. Sci 1019:85~95
Eefting, F. / 2004 / Role of apoptosis in reperfusion injury / Cardiovasc. Res 61:414~426
Engels, B. M. / 2006 / Principles and effects of microRNA-mediated post-transcriptional gene regulation / Oncogene 25:6163~6169
Dai, Y. / 2016 / The role of microRNA-1 and microRNA-206 in the proliferation and differentiation of bovine skeletal muscle satellite cells / In vitro Cell. Dev. Biol. Animal 52:27~34
Edwards, M. G. / 2004 / Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice / Ann. N Y Acad. Sci 1019:85~95
Eefting, F. / 2004 / Role of apoptosis in reperfusion injury / Cardiovasc. Res 61:414~426
Engels, B. M. / 2006 / Principles and effects of microRNA-mediated post-transcriptional gene regulation / Oncogene 25:6163~6169
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