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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 717 - 723 (7page)
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초록· 키워드
오류제보하기
Chimeric antigen receptor (CAR) T-cell therapy, an emerging immunotherapy, has demonstrated promising clinical results in hematological malignancies including B-cell malignancies. However, accessibility to this transformative medicine is highly limited due to the complex process of manufacturing, limited options for target antigens, and insufficient anti-tumor responses against solid tumors. Advances in gene-editing technologies, such as the development of Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9), have provided novel engineering strategies to address these limitations. Development of next-generation CAR-T cells using gene-editing technologies would enhance the therapeutic potential of CAR-T cell treatment for both hematologic and solid tumors. Here we summarize the unmet medical needs of current CAR-T cell therapies and gene-editing strategies to resolve these challenges as well as safety con-cerns of gene-edited CAR-T therapies.
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참고문헌 (50)
참고문헌 신청
Amir, A.L. / 2011 / Allo-HLA-Reactive T cells inducing graft-versus-host disease are single peptide specific / Blood 118:6733~6742
Chen, K.H. / 2017 / Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor / Leukemia 31:2151~2160
Cooper, M.L. / 2018 / An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies / Leukemia
Eyquem, J. / 2017 / Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection / Nature 543:113
Fleischer, L.C. / 2017 / Engineering CD5-targeted chimeric antigen receptors and edited T cells for the treatment of T-Cell Leukemia / Blood 130:1914~1914
Chen, K.H. / 2017 / Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor / Leukemia 31:2151~2160
Cooper, M.L. / 2018 / An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies / Leukemia
Eyquem, J. / 2017 / Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection / Nature 543:113
Fleischer, L.C. / 2017 / Engineering CD5-targeted chimeric antigen receptors and edited T cells for the treatment of T-Cell Leukemia / Blood 130:1914~1914
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