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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제6호
- 발행연도
- 2017.6
- 수록면
- 1,065 - 1,070 (6page)
- DOI
- 10.4014/jmb.1612.12009
이용수
초록· 키워드
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This study aimed to examine the anti-candidal efficacy of a novel ketone derivative isolated from Diaporthe sp. ED2, an endophytic fungus residing in medicinal herb Orthosiphon stamieus Benth. The ethyl acetate extract of the fungal culture was separated by open column and reverse phase high-performance liquid chromatography (HPLC). The eluent at retention time 5.64 min in the HPLC system was the only compound that exhibited anti-candidal activity on Kirby-Bauer assay. The structure of the compound was also elucidated by nuclear magnetic resonance and spectroscopy techniques. The purified anti-candidal compound was obtained as a colorless solid and characterized as 3-hydroxy-5-methoxyhex-5-ene-2,4-dione. On broth microdilution assay, the compound also exhibited fungicidal activity on a clinical strain of Candida albicans at a minimal inhibitory concentration of 3.1 μg/ml. The killing kinetic analysis also revealed that the compound was fungicidal against C. albicans in a concentration- and time-dependent manner. The compound was heat-stable up to 70°C, but its anti-candidal activity was affected at pH 2.
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참고문헌 (21)
참고문헌 신청
Quindós G. / 2014 / Epidemiology of candidaemia and invasive candidiasis. A changing face / Rev. Iberoam. Micol 31:42~48
Yapar N. / 2014 / Epidemiology and risk factors for invasive candidiasis / Ther. Clin. Risk Manag 10:95~105
Xiang MJ / 2013 / Erg11 mutations associated with azole resistance in clinical isolates of Candida albicans / FEMS Yeast Res 13:386~393
Pfeiffer CD / 2012 / Breakthrough invasive candidiasis in patients on microfungin / J. Clin. Microbiol 48:2373~2380
Tan RX / 2001 / Endophytes: a rich source of functional metabolites / Nat. Prod. Rep 18:448~459
Yapar N. / 2014 / Epidemiology and risk factors for invasive candidiasis / Ther. Clin. Risk Manag 10:95~105
Xiang MJ / 2013 / Erg11 mutations associated with azole resistance in clinical isolates of Candida albicans / FEMS Yeast Res 13:386~393
Pfeiffer CD / 2012 / Breakthrough invasive candidiasis in patients on microfungin / J. Clin. Microbiol 48:2373~2380
Tan RX / 2001 / Endophytes: a rich source of functional metabolites / Nat. Prod. Rep 18:448~459
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