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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제7호
- 발행연도
- 2017.7
- 수록면
- 1,276 - 1,280 (5page)
- DOI
- 10.4014/jmb.1611.11021
이용수
초록· 키워드
오류제보하기
The mcr-1 gene is a new “superbug” gene discoverd in China in 2016 that makes bacteria highly resistant to the last-resort class of antibiotics. The mcr-1 gene raised serious concern about its possible global dissemination and spread. Here, we report a potential anti-resistant strategy using the CRISPR/Cas9-mediated approach that can efficiently induce mcr-1 gene knockout in Escherichia coli. Our findings suggested that using the CRISPR/Cas9 system to knock out the resistance gene mcr-1 might be a potential anti-resistant strategy. Bovine myeloid antimicrobial peptide-27 could help deliver plasmid pCas::mcr targeting specific DNA sequences of the mcr-1 gene into microbial populations.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Liu YY / 2016 / Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China:a microbiological and molecular biological study / Lancet Infect. Dis 16:161~168
Chu HY / 2016 / Rhinovirus disease in children seeking care in a tertiary pediatric emergency department / J. Pediatr. Infect. Dis. Soc 5:29~38
Suzuki S / 2016 / Investigation of a plasmid genome database for colistin-resistance gene mcr-1 / Lancet Infect. Dis 16:284~285
Malhotra-Kumar S / 2016 / Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam / Lancet Infect. Dis 16:286~287
Stoesser N / 2016 / Colistin resistance gene mcr-1 and pHNSHP45 plasmid in human isolates of Escherichia coli and Klebsiella pneumoniae / Lancet Infect. Dis 16:285~286
Chu HY / 2016 / Rhinovirus disease in children seeking care in a tertiary pediatric emergency department / J. Pediatr. Infect. Dis. Soc 5:29~38
Suzuki S / 2016 / Investigation of a plasmid genome database for colistin-resistance gene mcr-1 / Lancet Infect. Dis 16:284~285
Malhotra-Kumar S / 2016 / Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam / Lancet Infect. Dis 16:286~287
Stoesser N / 2016 / Colistin resistance gene mcr-1 and pHNSHP45 plasmid in human isolates of Escherichia coli and Klebsiella pneumoniae / Lancet Infect. Dis 16:285~286
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