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논문 기본 정보

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학술저널
저자정보
Min Jae-Hong (Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju) Kim Seong-Man (Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju) Park JI-Won (Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju) Kwon Nam Hoon (Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju) Goo Soo Hyeon (Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju) Ngatinem (Starch Technology Center Agency for the Assessment and Application Technology Lampung 34161 Indones) Ningsih Sri (Center for Pharmaceutical and Medical Technology Agency for the Assessment and Application of Techn) Paik Jin-Hyub (International Biological Material Research Center Korea Research Institute of Bioscience and Biotec) Choi Sangho (International Biological Material Research Center Korea Research Institute of Bioscience and Biotec) 오세량 (NaturalMedicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju 2) Han Sang-Bae (College of Pharmacy Chungbuk National University Cheongju 28160 Republic of Korea) Ahn Kyung-Seop (Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju) Lee Jae-Won (Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology Cheongju)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제11호
발행연도
2021.11
수록면
1,501 - 1,507 (7page)
DOI
10.4014/jmb.2107.07023

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Lagerstroemia ovalifolia Teijsm. & Binn. (LO) (crape myrtle) has reportedly been used as traditional herbal medicine (THM) in Java, Indonesia. Our previous study revealed that the LO leaf extract (LOLE) exerted anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Based on this finding, the current study aimed to evaluate the protective effects of LOLE in a mouse model of LPS-induced acute lung injury (ALI). The results showed that treatment with LPS enhanced the inflammatory cell influx into the lungs and increased the number of macrophages and the secretion of the inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) of mice. However, these effects were notably abrogated with LOLE pretreatment. Furthermore, the increase of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein-1 (MCP-1) expression in the lung tissues of mice with ALI was also reversed by LOLE. In addition, LOLE significantly suppressed the LPS-induced activation of the MAPK/NF-κB signaling pathway and led to heme oxygenase-1 (HO-1) induction in the lungs. Additionally, in vitro experiments showed that LOLE enhanced the expression of HO-1 in RAW264.7 macrophages. The aforementioned findings collectively indicate that LOLE exerts an ameliorative effect on inflammatory response in the airway of ALI mice.
#Acute lung injury #Lagerstroemia ovalifolia leaf extract #cytokines #NF-κB #HO-1

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참고문헌 (33)

참고문헌 신청
Butt Y / 2016 / Acute lung injury : a clinical and molecular review / Arch. Pathol. Lab. Med 140:345~350 google schola Huang X / 2018 / The role of macrophages in the pathogenesis of ALI/ARDS / Mediators Inflamm 13:1264913 google schola 박지원 / 2020 / The Anti-Inflammatory Effect of Trichilia martiana C. DC. in the Lipopolysaccharide- Stimulated Inflammatory Response in Macrophages and Airway Epithelial Cells and in LPS-Challenged Mice / Journal of Microbiology and Biotechnology 30(11):1614~1625 dbpia Chen X / 2020 / Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome / Inflamm. Res 69:883~895 google schola Frank JA / 2003 / High tidal volume ventilation induces NOS2 and impairs cAMPdependent air space fluid clearance / Am. J. Physiol. Lung. Cell. Mol. Physiol 284:L791~798 google schola

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