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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 1,095 - 1,104 (10page)
- DOI
- 10.1007/s13258-021-01138-4
이용수
초록· 키워드
오류제보하기
Background Ovarian cancer is the most common female gynecological malignancy. SNHG20, as a long non-coding RNA, has been proven to be an important regulator in the occurrence and development of various tumors. However, the potential mechanism of SNHG20 in ovarian cancer is unclear.
Objective The present study was aimed to investigate the functions and mechanisms of SNHG20 in ovarian cancer.
Methods The expression of SNHG20 and miR-217 in ovarian cancer tissues and cell lines was detected by qRT-PCR. CCK-8 assay was used to measure cell proliferation in transfected cells. The transwell assay was used to detect the relative invasion rate of transfected cells. The putative binding sites between SNHG20 and miR-217 were predicted by software LncBase v.2, and the interaction between SNHG20 and miR-217 was confrmed by dual-luciferase reporter assays and RIP assay. The rescue experiments were used to illustrate potential mechanisms.
Results SNHG20 was upregulated in ovarian cancer tissues and cell lines. Overexpression of SNHG20 promoted ovarian cancer cell proliferation and invasion. MiR-217 was downregulated in ovarian cancer tissues and cells, and was negatively regulated by SNHG20. Moreover, miR-217 overexpression inhibited ovarian cancer cell proliferation and invasion. Furthermore, miR-217 mimic reversed the inhibitory efect of SNHG20 overexpression on the biological behavior of ovarian cancer cells.
Conclusions SNHG20 promoted cell proliferation and invasion by sponging miR-217 in ovarian cancer. These results suggested that SNHG20 and miR-217 might provide new targets for therapeutic application in ovarian cancer.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
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Bartel D / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Bill M / 2019 / Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells / Leukemia 33:2169~2182
Cao Y / 2020 / Long noncoding RNA UCA1 regulates PRL-3 expression by sponging microRNA-495 to promote the progression of gastric cancer / Mol Ther Nucleic Acids 19:853~864
Chang L / 2018 / LncRNA HOTAIR regulates CCND1 and CCND2 expression by sponging miR-206in ovarian cancer / Cell Physiol Biochem 49:1289~1303
Bartel D / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Bill M / 2019 / Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells / Leukemia 33:2169~2182
Cao Y / 2020 / Long noncoding RNA UCA1 regulates PRL-3 expression by sponging microRNA-495 to promote the progression of gastric cancer / Mol Ther Nucleic Acids 19:853~864
Chang L / 2018 / LncRNA HOTAIR regulates CCND1 and CCND2 expression by sponging miR-206in ovarian cancer / Cell Physiol Biochem 49:1289~1303
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