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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제40권 제3호
- 발행연도
- 2018.3
- 수록면
- 1 - 8 (8page)
- DOI
- https://doi.org/10.1186/s40902-018-0146-4
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초록· 키워드
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Background: The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo.Methods: Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline (n = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis.Results: The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group (P < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group (P < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides (P < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side.Conclusion: BTX-A injection into the masseter muscle influences mandibular bone growth.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Pearce LB / 1994 / Measurement of botulinum toxin activity: evaluation of the lethality assay / Toxicol Appl Pharmacol 128:69~77
Moon YM / 2016 / Apoptotic action of botulinum toxin on masseter muscle in rats: early and late changes in the expression of molecular markers / Spring 5:1~11
Young-Min Moon / 2015 / Early effect of Botox-A injection into the masseter muscle of rats: functional and histological evaluation / Maxillofacial Plastic Reconstructive Surgery 37(12):1~6
권대근 / 2016 / Botulinum toxin related research in maxillofacial plastic and reconstructive surgery / Maxillofacial Plastic Reconstructive Surgery 38(9):1~2
Maio MD / 2008 / Therapeutic uses of botulinum toxin: from facial palsy to autonomic disorders / Expert Opin Biol Ther 8:791~798
Moon YM / 2016 / Apoptotic action of botulinum toxin on masseter muscle in rats: early and late changes in the expression of molecular markers / Spring 5:1~11
Young-Min Moon / 2015 / Early effect of Botox-A injection into the masseter muscle of rats: functional and histological evaluation / Maxillofacial Plastic Reconstructive Surgery 37(12):1~6
권대근 / 2016 / Botulinum toxin related research in maxillofacial plastic and reconstructive surgery / Maxillofacial Plastic Reconstructive Surgery 38(9):1~2
Maio MD / 2008 / Therapeutic uses of botulinum toxin: from facial palsy to autonomic disorders / Expert Opin Biol Ther 8:791~798
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