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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제37권 제12호
- 발행연도
- 2015.12
- 수록면
- 1 - 6 (6page)
- DOI
- 10.1186/s40902-015-0049-6
이용수
초록· 키워드
오류제보하기
Background: The purpose of this study was to evaluate the change of food intake after different dosages ofbotulinum toxin A (BTX) injection in the animal model. Additionally, the dimensional and histological change at14 days after BTX injection was also evaluated.
Methods: The comparative study was performed using the BTX injection model in rats (n = 5 for each group).
Group 1 was the saline-injected group. Group 2 was the 5-unit BTX-injection group to each masseter muscle. Group3 was the 10-unit BTX-injection group to each masseter muscle. Food intake rates and body weight were checkeddaily before and after BTX injection until 10 days. All animals were sacrificed at 14 days after BTX injection, and thespecimens underwent hematoxylin and eosin stain and immunohistochemical staining for myosin type II (MYH2).
Results: The recovery of food intake in groups 2 and 3 decreased significantly compared with group 1 from day 2to day 7 and day 9 after injection (p < 0.05). The BTX-treated masseter muscles were significantly smaller thanthose in group 1 (p = 0.015). The immunohistochemical findings demonstrated that the expression of MYH2 wassignificantly higher in group 3 compared to groups 1 and 2 (p < 0.001).
Conclusions: BTX injection to the masseter muscle in rats demonstrated short food-intake-rate reduction withrecovery until 10 days after injection. The thickness of the masseter muscle and MYH2 expression were significantlychanged according to the injected dose of BTX.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Kiris E / 2014 / Recent advances in botulinum neurotoxin inhibitor development / Curr Top Med Chem 14(18):2044~2061
Tan EK / 2000 / Treating severe bruxism with botulinum toxin / J Am Dent Assoc 131:211~216
Watts MW / 1999 / Bruxism and cranial-cervical dystonia: is there a relationship? / Cranio 17:196~201
Molina OF / 1997 / Prevalence of modalities of headaches and bruxism among patients with craniomandibular disorder / Cranio 15:314~325
Santamato A / 2008 / Botulinum toxin type A in the treatment of sialorrhea in Parkinson’s disease / J Am Geriatr Soc 56:765~767
Tan EK / 2000 / Treating severe bruxism with botulinum toxin / J Am Dent Assoc 131:211~216
Watts MW / 1999 / Bruxism and cranial-cervical dystonia: is there a relationship? / Cranio 17:196~201
Molina OF / 1997 / Prevalence of modalities of headaches and bruxism among patients with craniomandibular disorder / Cranio 15:314~325
Santamato A / 2008 / Botulinum toxin type A in the treatment of sialorrhea in Parkinson’s disease / J Am Geriatr Soc 56:765~767
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