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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 144 - 149 (6page)
- DOI
- https://doi.org/10.1186/s40824-017-0102-x
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초록· 키워드
오류제보하기
Background: The injection of botulinum toxin (BTX) to reduce facial wrinkles is one of the most frequently performed plastic surgery procedures. The biocompatible hydrogels are injected with BTX for effective tissue augmentation. However, it is difficult to determine the interval of injection for effective tissue augmentation. Method: BTX and hyaluronate (HA) hydrogels were labeled with zwitterionic (ZW) near-infrared (NIR) fluorophores and visualized for 3 weeks after injection to BALB/c nude mice. Results: BTX-ZW conjugates and diaminohexane (DAH)-HA-ZW hydrogels were successfully prepared by the conventional EDC/NHS chemistry. Using the NIR fluorescence imaging, we confirmed that approximately 10% of BTX-ZW conjugates and 50% of DAH-HA-ZW hydrogels remained 3 weeks post-injection. Conclusion: This bioimaging technique using invisible NIR fluorescence light can be exploited for various biomedical applications.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Small R / 2014 / Botulinum toxin injection for facial wrinkles / Am Fam Physician 90:168~175
Montecucco C / 2015 / Botulinal neurotoxins : revival of an old killer / Curr Opin Pharmacol 5:274~279
Dressler D / 2007 / Pharmacology of therapeutic botulinum toxin preparations / Disabil Rehabil 29:1761~1768
Peng L / 2013 / Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival / Nat Commun 4:1472
Coleman KR / 2006 / Combination therapy with BOTOX™ and fillers : the new rejuvenation paradigm / Dermatol Ther 19:177~188
Montecucco C / 2015 / Botulinal neurotoxins : revival of an old killer / Curr Opin Pharmacol 5:274~279
Dressler D / 2007 / Pharmacology of therapeutic botulinum toxin preparations / Disabil Rehabil 29:1761~1768
Peng L / 2013 / Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival / Nat Commun 4:1472
Coleman KR / 2006 / Combination therapy with BOTOX™ and fillers : the new rejuvenation paradigm / Dermatol Ther 19:177~188
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