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논문 기본 정보

자료유형
학술저널
저자정보
조진경 (성균관대학교) 박수현 (성균관대학교) 강현식 (성균관대학교)
저널정보
한국운동생리학회 운동과학 운동과학 제26권 제3호
발행연도
2017.8
수록면
223 - 228 (6page)
DOI
https://doi.org/10.15857/ksep.2017.26.3.223

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초록· 키워드

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PURPOSE: This study investigated the protective role of high-intensity interval training against acute liver injury induced by D-galactosamine (D-Gal)/lipopolysaccharide (LPS). METHODS: A total of 30 male BALB/c mice aged 5-week were randomly assigned to high-intensity, interval training group (EX, n=10) or control group in cage (Non-EX, n=20) for 10 weeks. Peritoneal injection of D-Gal (700 mg/kg body weight) and LPS (10 μg/kg body weight) was applied to induce acute liver injury, and liver tissue was harvested 6 h after the injection. Hematoxylin and Eosin (H&E) staining was used for liver histology. Real-time PCR was used to quantify expression of pro-inflammatory and anti-inflammatory genes in the liver. RESULTS: The liver histology showed that D-Gal/LPS treatment resulted in hepatic damage and increased number of neutrophils in conjunction with upregulation of hepatic IL-6 and TNF-α mRNAs and downregulation of hepatic PPARα and SIRT1 mRNAs. On the other hand, the 10-week interval training resulted in a significant improvement in cardiorespiratory fitness assessed as run time to exhaustion on a treadmill. In addition, the interval training attenuated the D-Gal/LPS-induced liver damage and increased number of neutrophil in conjunction with downregulation of hepatic IL-6 and TNF-α mRNAs and upregulation of hepatic PPARα and SIRT1 mRNAs. CONCLUSIONS: This study suggests that high-intensity interval training suppresses the D-Gal and LPS-induced acute liver damage and inflammatory responses.

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