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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 19 - 27 (9page)
- DOI
- 10.1186/s40824-018-0117-y
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초록· 키워드
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Background: Biomaterials that promote the self-renewal ability and differentiation capacity of neural stem cells (NSCs) are desirable for improving stem cell therapy to treat neurodegenerative diseases. Incorporation of micro- and nanoparticles into stem cell culture has gained great attention for the control of stem cell behaviors, including proliferation and differentiation. Method: In this study, ferritin, an iron-containing natural protein nanoparticle, was applied as a biomaterial to improve the self-renewal and differentiation of NSCs and neural progenitor cells (NPCs). Ferritin nanoparticles were added to NSC or NPC culture during cell growth, allowing for incorporation of ferritin nanoparticles during neurosphere formation. Results: Compared to neurospheres without ferritin treatment, neurospheres with ferritin nanoparticles showed significantly promoted self-renewal and cell-cell interactions. When spontaneous differentiation of neurospheres was induced during culture without mitogenic factors, neuronal differentiation was enhanced in the ferritin-treated neurospheres. Conclusions: In conclusion, we found that natural nanoparticles can be used to improve the self-renewal ability and differentiation potential of NSCs and NPCs, which can be applied in neural tissue engineering and cell therapy for neurodegenerative diseases.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Hardy J / 2002 / The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics / Science 297:353~356
Reeve A / 2014 / Ageing and Parkinson's disease: why is advancing age the biggest risk factor? / Ageing Res Rev 14:19~30
Rossi F / 2002 / Neural stem cell therapy for neurological diseases: dreams and reality / Nat Rev Neurosci 3:401~409
Martino G / 2006 / The therapeutic potential of neural stem cells / Nat Rev Neurosci 7:395~406
Hong S / 2013 / Hyaluronic acid catechol: a biopolymer exhibiting a pH-dependent adhesive or cohesive property for human neural stem cell engineering / Adv Funct Mater 23:1774~1780
Reeve A / 2014 / Ageing and Parkinson's disease: why is advancing age the biggest risk factor? / Ageing Res Rev 14:19~30
Rossi F / 2002 / Neural stem cell therapy for neurological diseases: dreams and reality / Nat Rev Neurosci 3:401~409
Martino G / 2006 / The therapeutic potential of neural stem cells / Nat Rev Neurosci 7:395~406
Hong S / 2013 / Hyaluronic acid catechol: a biopolymer exhibiting a pH-dependent adhesive or cohesive property for human neural stem cell engineering / Adv Funct Mater 23:1774~1780
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