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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 52 - 58 (7page)
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Neural stem cells (NSCs), with self-renewal and neuronal differentiation capacity, are a feasible resource in cellbased therapies for various neurodegenerative diseases and neural tissue injuries. In this study, we investigated the effects of Schisandrae Fructus (SF) on proliferation and differentiation of human embryonic NSCs. Treatment with 70% ethanol extract of SF increased the viability of NSCs derived from human embryonic stem cells, which was accompanied by increased mRNA expression of cyclin D1. Whereas 70% ethanol extract of SF also decreased the mRNA expression of nestin, it increased class III β-tublin (Tuj-1) and MAP2 in both growth and differentiation media. Lastly, we found increased mRNA expression of BDNF in SF-treated NSCs. In conclusion, our study demonstrates for the first time that SF induced proliferation and neuronal differentiation of NSCs and increased mRNA expression of BDNF, suggesting its potential as a regulator of NSC fate in NSCbased therapy for neuronal injuries from various diseases.
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참고문헌 (25)
참고문헌 신청
Reynolds, B. A. / 1992 / A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes / J. Neurosci 12:4565~4574
Kim, S. U. / 1999 / Neural stem cell-based treatment for neurodegenerative diseases / Neuropathology 33:491~504
Hao, L. / 2014 / Stem cell-based therapies for ischemic stroke / Biomed. Res. Int :468748
Wernig, M. / 2008 / Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease / Proc. Natl. Acad. Sci. U. S. A 105:5856~5861
Kriks, S. / 2011 / Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease / Nature 480:547~551
Kim, S. U. / 1999 / Neural stem cell-based treatment for neurodegenerative diseases / Neuropathology 33:491~504
Hao, L. / 2014 / Stem cell-based therapies for ischemic stroke / Biomed. Res. Int :468748
Wernig, M. / 2008 / Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease / Proc. Natl. Acad. Sci. U. S. A 105:5856~5861
Kriks, S. / 2011 / Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease / Nature 480:547~551
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