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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 698 - 707 (10page)
- DOI
- 10.4093/dmj.2020.0118
이용수
초록· 키워드
오류제보하기
Background: This study aimed to investigate the association between hepatic steatosis burden and albuminuria in Korean patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD).Methods: We recruited 100 patients with both T2DM and NAFLD, but without chronic kidney disease. Albuminuria was defined as a spot urinary albumin-to-creatinine ratio (ACR) ≥30 mg/g. Transient elastography was performed, and the steatosis burden was quantified by controlled attenuation parameter (CAP) with significant steatosis defined as CAP >302 dB/m.Results: The prevalence of significant steatosis and albuminuria was 56.0% and 21.0%, respectively. Subjects with significant steatosis were significantly younger and had a significantly shorter duration of T2DM, greater waist circumference, and higher body mass index, total cholesterol, triglyceride, and low density lipoprotein cholesterol levels, than subjects without severe NAFLD (all P<0.05). Albuminuria was higher in patients with significant steatosis than in patients without significant steatosis (32.1% vs. 6.8%, P=0.002). Urinary ACR showed a correlation with CAP (r=0.331, P=0.001), and multiple linear regression analysis revealed a significant association between a high degree of albuminuria and high CAP value (r=0.321, P=0.001). Additionally, multivariate logistic regression analysis demonstrated the independent association between urinary ACR and significant steatosis after adjustment for confounding factors including age, body mass index, duration of T2DM, low density lipoprotein level, and renin-angiotensin system blocker use (odds ratio, 1.88; 95% confidence interval, 1.31 to 2.71; P=0.001).Conclusion: T2DM patients with NAFLD had a higher prevalence of albuminuria, which correlated with their steatosis burden.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease : meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:73~84
Younossi ZM / 2019 / The global epidemiology of NAFLD and NASH in patients with type 2 diabetes : a systematic review and meta-analysis / J Hepatol 71:793~801
Kanwal F / 2016 / Trends in the burden of nonalcoholic fatty liver disease in a United States cohort of veterans / Clin Gastroenterol Hepatol 14:301~308
이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45
Torres DM / 2012 / Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma : fertile soil / Semin Liver Dis 32:30~38
Younossi ZM / 2019 / The global epidemiology of NAFLD and NASH in patients with type 2 diabetes : a systematic review and meta-analysis / J Hepatol 71:793~801
Kanwal F / 2016 / Trends in the burden of nonalcoholic fatty liver disease in a United States cohort of veterans / Clin Gastroenterol Hepatol 14:301~308
이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45
Torres DM / 2012 / Nonalcoholic steatohepatitis and noncirrhotic hepatocellular carcinoma : fertile soil / Semin Liver Dis 32:30~38
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