지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 739 - 752 (14page)
- DOI
- 10.4093/dmj.2020.0137
이용수
초록· 키워드
오류제보하기
Background: Several noninvasive tools are available for the assessment of nonalcoholic fatty liver disease (NAFLD) including clinical and blood biomarkers, transient elastography (TE), and magnetic resonance imaging (MRI) techniques, such as proton density fat fraction (MRI-PDFF) and magnetic resonance elastography (MRE). In the present study, we aimed to evaluate whether magnetic resonance (MR)-based examinations better discriminate the pathophysiologic features and fibrosis progression in NAFLD than other noninvasive methods.Methods: A total of 133 subjects (31 healthy volunteers and 102 patients with NAFLD) were subjected to clinical and noninvasive NAFLD evaluation, with additional liver biopsy in some patients (n=54).Results: MRI-PDFF correlated far better with hepatic fat measured by MR spectroscopy (r=0.978, P<0.001) than with the TE controlled attenuation parameter (CAP) (r=0.727, P<0.001). In addition, MRI-PDFF showed stronger correlations with various pathophysiologic parameters for cellular injury, glucose and lipid metabolism, and inflammation, than the TE-CAP. The MRI-PDFF and TE-CAP cutoff levels associated with abnormal elevation of serum alanine aminotransferase were 9.9% and 270 dB/m, respectively. The MRE liver stiffness measurement (LSM) showed stronger correlations with liver enzymes, platelets, complement component 3, several clinical fibrosis scores, and the enhanced liver fibrosis (ELF) score than the TE-LSM. In an analysis of only biopsied patients, MRE performed better in discriminating advanced fibrosis with a cutoff value of 3.9 kPa than the TE (cutoff 8.1 kPa) and ELF test (cutoff 9.2 kPa).Conclusion: Our results suggest that MRI-based assessment of NAFLD is the best non-invasive tool that captures the histologic, pathophysiologic and metabolic features of the disease.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Younossi ZM / 2016 / Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes / Hepatology 64:73~84
이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45
Portillo-Sanchez P / 2015 / High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels / J Clin Endocrinol Metab 100:2231~2238
Musso G / 2011 / Meta-analysis : natural history of non-alcoholic fatty liver disease(NAFLD)and diagnostic accuracy of non-invasive tests for liver disease severity / Ann Med 43:617~649
Ekstedt M / 2015 / Fibrosis stage is the strongest predictor for diseasespecific mortality in NAFLD after up to 33 years of follow-up / Hepatology 61:1547~1554
이용호 / 2019 / Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis / Diabetes and Metabolism Journal 43(1):31~45
Portillo-Sanchez P / 2015 / High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels / J Clin Endocrinol Metab 100:2231~2238
Musso G / 2011 / Meta-analysis : natural history of non-alcoholic fatty liver disease(NAFLD)and diagnostic accuracy of non-invasive tests for liver disease severity / Ann Med 43:617~649
Ekstedt M / 2015 / Fibrosis stage is the strongest predictor for diseasespecific mortality in NAFLD after up to 33 years of follow-up / Hepatology 61:1547~1554
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future
Clinical and Molecular Hepatology
2023 .02
-
Magnetic Resonance Elastography and Other Magnetic Resonance Imaging Techniques in Chronic Liver Disease: Current Status and Future Directions
Gut and Liver
2016 .01
-
Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease
Endocrinology and Metabolism
2020 .01
-
Identification of high-risk subjects in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .02
-
Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea
예방의학회지
2021 .11
-
Noninvasive Assessment of Advanced Fibrosis Based on Hepatic Volume in Patients with Nonalcoholic Fatty Liver Disease
Gut and Liver
2017 .01
-
Noninvasive serum biomarkers for liver fibrosis in NAFLD: current and future
Clinical and Molecular Hepatology
2023 .02
-
New Perspectives in Pediatric Nonalcoholic Fatty Liver Disease: Epidemiology, Genetics, Diagnosis, and Natural History
Pediatric Gastroenterology, Hepatology & Nutrition
2019 .01
-
Current role of transient elastography in the management of chronic hepatitis B patients
ULTRASONOGRAPHY
2017 .01
-
Updates in the quantitative assessment of liver fibrosis for nonalcoholic fatty liver disease: Histological perspective
Clinical and Molecular Hepatology
2021 .01
-
Application of transient elastography in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2020 .01
-
Screening strategy for non-alcoholic fatty liver disease
Clinical and Molecular Hepatology
2023 .02
-
Can Magnetic Resonance Elastography Fill a Niche in the Market for Noninvasive Assessment of Liver Fibrosis?
Gut and Liver
2017 .01
-
Non-alcoholic Fatty Liver Disease (NAFLD) and Significant Hepatic Fibrosis Defined by Non-invasive Assessment in Patients with Type 2 Diabetes
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Non-invasive biomarkers for liver inflammation in non-alcoholic fatty liver disease: present and future
Clinical and Molecular Hepatology
2023 .02
-
Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
Diabetes and Metabolism Journal
2019 .01
-
Non-invasive imaging biomarkers for liver steato- sis in non-alcoholic fatty liver disease: present and future
Clinical and Molecular Hepatology
2023 .04
-
Non-Laboratory-Based Simple Screening Model for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Developed Using Multi-Center Cohorts
Endocrinology and Metabolism
2021 .08
-
Nonalcoholic fatty liver disease and non-liver comorbidities
Clinical and Molecular Hepatology
2023 .02
-
Clinical application of liver stiffness measurement for assessing the risk of hepatocellular Carcinoma
Journal of Liver Cancer
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0