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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 409 - 419 (11page)
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Inflammation is a defensive response to external stimuli such as wounds and infections. However, excessive inflammation causes chronic inflammatory disease through the overexpression of inflammatory mediators such as nitric oxide (NO) and prostaglandin (PG) E2, and inflammatory cytokines such as interleukins (ILs). This study aimed to investigate the anti-inflammatory effects of methanolic extract of clover (MEC) and red clover (MERC) on lipopolysaccharide (LPS)-stimulated immune responses in RAW 264.7 cells. MEC and MERC (0, 62.5, 125, 250, and 500 μg/mL) were pretreated for an hour before stimulation with LPS (1 μg/mL). MEC and MERC did not exhibit cytotoxicity under 500 μg/mL and inhibited the production of inflammatory mediators such as NO and PGE2. In addition, MEC and MERC suppressed the LPS-induced expression of proinflammatory cytokines, including IL-6 and IL-1β at the mRNA and protein levels in RAW 264.7. The overall findings of this study suggest that MEC and MERC can be used as treatments for various inflammatory diseases.
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참고문헌 (35)
참고문헌 신청
Ahmad, S. / 2021 / Phytochemical profile and pharmacological properties of Trifolium repens / J Basic Clin Physiol Pharmacol 32:20200015
Boumpas, D. T. / 1993 / Glucocorticoid therapy of immunemediated diseases, basic and clinical correlates / Ann Intern Med 119:1198~1208
전명숙 / 2009 / 마우스 Raw 264.7 세포에 대한 4종 대황류 추출물의 항염증 활성 비교 / 한국약용작물학회지 17(2):109~114
Chung, Y. C. / 2018 / Anti-inflammatory effect of pratol in LPS-stimulated RAW 264.7 cells via NF-κB signaling pathways / Natural Product Communications 13:547~550
Esmaeili, A. K. / 2015 / Antioxidant activity and total phenolic and flavonoid content of various solvent extracts from in vivo and in vitro grown Trifolium pratense L. (Red Clover) / BioMed Res Int 2015:1~11
Boumpas, D. T. / 1993 / Glucocorticoid therapy of immunemediated diseases, basic and clinical correlates / Ann Intern Med 119:1198~1208
전명숙 / 2009 / 마우스 Raw 264.7 세포에 대한 4종 대황류 추출물의 항염증 활성 비교 / 한국약용작물학회지 17(2):109~114
Chung, Y. C. / 2018 / Anti-inflammatory effect of pratol in LPS-stimulated RAW 264.7 cells via NF-κB signaling pathways / Natural Product Communications 13:547~550
Esmaeili, A. K. / 2015 / Antioxidant activity and total phenolic and flavonoid content of various solvent extracts from in vivo and in vitro grown Trifolium pratense L. (Red Clover) / BioMed Res Int 2015:1~11
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