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논문 기본 정보

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학술저널
저자정보
Kim Seon Ju (Department of Anesthesiology and Pain Medicine National Health Insurance Service Ilsan Hospital) 김소연 (연세대학교) Lee Hye Sun (Yonsei University College of Medicine) Park Goeun (Yonsei University College of Medicine) Yoon Eun Jang (Department of Anesthesiology and Pain Medicine Yonsei University College of Medicine) Heo Sungtaik (Department of Anesthesiology and Pain Medicine National Health Insurance Service Ilsan Hospital) 구본녀 (연세대학교)
저널정보
대한마취통증의학회(구 대한마취과학회) Anesthesia and Pain Medicine Anesthesia and Pain Medicine Vol.16 No.4
발행연도
2021.10
수록면
360 - 367 (8page)
DOI
10.17085/apm.21001

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Background: Dynamic preload indices may predict fluid responsiveness in end-stage liver disease. However, their usefulness in patients with altered vascular compliance is uncertain. This study is the first to evaluate whether dynamic indices can reliably predict fluid responsiveness in patients undergoing liver transplantation with a high femoral-to-radial arterial pressure gradient (PG).Methods: 80 liver transplant recipients were retrospectively categorized as having a normal (n = 56) or high (n = 24, difference in systolic pressure ≥ 10 mmHg and/or mean pressure ≥ 5 mmHg) femoral-to-radial arterial PG, measured immediately after radial and femoral arterial cannulation. The ability of dynamic preload indices (stroke volume variation, pulse pressure variation [PPV], pleth variability index) to predict fluid responsiveness was assessed before the surgery. Fluid replacement of 500 ml of crystalloid solution was performed over 15 min. Fluid responsiveness was defined as ≥ 15% increase in the stroke volume index. The area under the receiver-operating characteristic curve (AUC) indicated the prediction of fluid responsiveness.Results: Fourteen patients in the normal, and eight in the high PG group were fluid responders. The AUCs for PPV in the normal, high PG groups and total patients were 0.702 (95% confidence interval [CI] 0.553?0.851, P = 0.008), 0.633 (95% CI 0.384?0.881, P = 0.295) and 0.667 (95% CI 0.537?0.798, P = 0.012), respectively. No other index predicted fluid responsiveness.Conclusion: PPV can be used as a dynamic index of fluid responsiveness in patients with end-stage liver disease but not in patients with altered vascular compliance.

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