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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제4호
- 발행연도
- 2016.7
- 수록면
- 325 - 332 (8page)
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초록· 키워드
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Resveratrol, a phytoalexin, is reported to activate AMP-activated protein kinase (AMPK) in vascular cells. The blood-brain barrier (BBB), formed by specialized brain endothelial cells that are interconnected by tight junctions, strictly regulates paracellular permeability to maintain an optimal extracellular environment for brain homeostasis. The aim of this study was to elucidate the effects of resveratrol and the role of AMPK in BBB dysfunction induced by lipopolysaccharide (LPS). Exposure of human brain microvascular endothelial cells (HBMECs) to LPS (1 μg/ml) for 4 to 24 hours week dramatically increased the permeability of the BBB in parallel with lowered expression levels of occluding and claudin-5, which are essential to maintain tight junctions in HBMECs. In addition, LPS significantly increased the reactive oxygen species (ROS) productions. All effects induced by LPS in HBVMCs were reversed by adenoviral overexpression of superoxide dismutase, inhibition of NAD(P) H oxidase by apocynin or gain-function of AMPK by adenoviral overexpression of constitutively active mutant (AMPK-CA) or by resveratrol. Finally, upregulation of AMPK by either AMPK-CA or resveratrol abolished the levels of LPS-enhanced NAD(P)H oxidase subunits protein expressions. We conclude that AMPK activation by resveratrol improves the integrity of the BBB disrupted by LPS through suppressing the induction of NAD(P)H oxidase-derived ROS in HBMECs.
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참고문헌 (31)
참고문헌 신청
이병환 / 2013 / Resveratrol Inhibits GABAC ρ Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes / The Korean Journal of Physiology & Pharmacology 17(2):175~180
Xu Q / 2012 / Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action / Nutr Res 32:648~658
Signorelli P / 2005 / Resveratrol as an anticancer nutrient : molecular basis, open questions and promises / J Nutr Biochem 16:449~466
Jang M / 1997 / Cancer chemopreventive activity of resveratrol, a natural product derived from grapes / Science 275:218~220
Hamza SM / 2014 / Systemic and renal oxidative stress in the pathogenesis of hypertension : modulation of long-term control of arterial blood pressure by resveratrol / Front Physiol 5:292
Xu Q / 2012 / Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action / Nutr Res 32:648~658
Signorelli P / 2005 / Resveratrol as an anticancer nutrient : molecular basis, open questions and promises / J Nutr Biochem 16:449~466
Jang M / 1997 / Cancer chemopreventive activity of resveratrol, a natural product derived from grapes / Science 275:218~220
Hamza SM / 2014 / Systemic and renal oxidative stress in the pathogenesis of hypertension : modulation of long-term control of arterial blood pressure by resveratrol / Front Physiol 5:292
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