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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 829 - 834 (6page)
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초록· 키워드
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Free radicals originate due to the radiolysis of cytoplasmic water with low “Linear Energy Transfer” (LET) radiations. Naringenin (Ng) is a natural antioxidative compound found in citrus fruits. This study revealed that Naringenin (Ng) reduced the radiation damage of critical organs by scavenging oxidative free radicals. In the study, Ng was orally administrated to rats daily for 7 consecutive days, prior to whole body exposure to gamma-rays. The scavenging efficacy was evaluated biochemically by measuring the concentration of cytotoxic byproducts and the activity of enzymes relevant to oxidative free radicals, after extracting the organs from the exposed rat. We observed increased levels of malondialdehyde (MDA) concentration, and decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) in the exposed control group. However, pretreatment with Ng significantly reduced the MDA concentration, and increased the activities of SOD and CAT, as compared to the control group, due to the free radical scavenging by Ng. The results indicate that Ng administration prior to irradiation could protect critical organs from radiation damage.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Apel K / 2004 / Reactive oxygen species : metabolism, oxidative stress, and signal transduction / Annu Rev Plant Biol 55:373~399
Ayala A / 2014 / Lipid peroxidation : production, metabolism, and signaling mechanisms of Malondialdehyde and 4-Hydroxy-2-nonenal / Oxid Med Cell Longev 2014:31
Azzam EI / 2012 / Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury / Cancer Lett 327:48~60
Benkovic V / 2009 / Evaluation of radioprotective effects of propolis and its flavonoid constituents : In vitro study on human white blood cells / PTR 23:1159~1168
Cavia Saiz M / 2010 / Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study / J. Sci. Food Agr 90:1238~1244
Ayala A / 2014 / Lipid peroxidation : production, metabolism, and signaling mechanisms of Malondialdehyde and 4-Hydroxy-2-nonenal / Oxid Med Cell Longev 2014:31
Azzam EI / 2012 / Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury / Cancer Lett 327:48~60
Benkovic V / 2009 / Evaluation of radioprotective effects of propolis and its flavonoid constituents : In vitro study on human white blood cells / PTR 23:1159~1168
Cavia Saiz M / 2010 / Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study / J. Sci. Food Agr 90:1238~1244
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