Effects of Apium graveolens Extract on the Oxidative Stress in the Liver of Adjuvant-Induced Arthritic Rats

Wanida Sukketsiri; Pennapa Chonpathompikunlert; Supita Tanasawet; Nutjanat Choosri; Tulaporn Wongtawatchai

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자료유형: 학술저널

저자정보: Wanida Sukketsiri (Prince of Songkla University) Pennapa Chonpathompikunlert (Prince of Songkla University) Supita Tanasawet (Prince of Songkla University) Nutjanat Choosri (Prince of Songkla University) Tulaporn Wongtawatchai (Prince of Songkla University)

저널정보: 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.2

발행연도: 2016.6

수록면: 79 - 84 (6page)

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Apium graveolens Linn. (Apiaceae) is an indigenous plant of the North and South Americas, Southern Europe, and Asia and has been widely used as a food or a traditional medicine for treatment of inflammation and arthritis. The purpose of this study was to investigate the antioxidant effects of a methanolic extract of A. graveolens (AGE) against liver oxidative stress in an adjuvant-induced arthritic rat model. The AGE (250, 500, and 1,000 ㎎/㎏) was given orally for 24 consecutive days after induction by injecting complete Freund’s adjuvant. Liver and spleen weights were recorded. The superoxide anion level, total peroxide (TP), glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, total antioxidant status, and oxidative stress index (OSI) were also measured. AGE treatment significantly decreased the levels of the superoxide anion, TP, and OSI whereas the GPx and SOD activities significantly increased in the liver of the arthritic rats. These results indicated that AGE showed an ameliorative effect against liver oxidative stress in adjuvant-induced arthritic rats by reducing the generation of liver free radicals and increasing the liver antioxidant enzyme activity.

#Chinese celery #rheumatoid arthritis #adjuvant-induced arthritis #reactive oxygen species #liver oxidative stress

참고문헌 (37)

참고문헌 신청

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