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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 133 - 137 (5page)
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초록· 키워드
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Curcumin is a hydrophobic polyphenol extracted from turmeric that exhibits a variety of biological functions has albeit with limited efficacy as a functional food material owing to its low absorption when administered orally. The newly developed curcumin powder formulation exhibits improved absorption rate in vivo. This study evaluates the anti-oxidant effects of Theracurmin® (TC), which is highly bio-available in curcumin powder. The antioxidant activity of TC was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferrous reducing antioxidant power (FRAP) assays, NO radical, superoxide radical, H2O2 scavenging activity, and total antioxidant capacity (TAC). Additionally, we evaluated the antioxidant activity of TC in high-fat diet (HFD)-fed streptozotocin (STZ)-induced Type 2 diabetic rats. As a result of oral administration of TC for 13 weeks in type 2 diabetic rats, the group administration of 2,000 mg/kg significantly increased FRAP, superoxide dismutase (SOD), and reduced the level of glutathione (GSH) in liver tissue 1.9, 1.2, and 1.2-times, respectively. Furthermore, serum TAC levels increased by 1.3-fold after the rats were administered with a dose of 500 mg/kg. These results were consistent with the in vitro assay results. In conclusion, TC exhibited its potential as a functional food material through its antioxidant properties. Key words: curcumin, theracurmin, antioxidant activity, high-fat diet, streptozotocin
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참고문헌 (17)
참고문헌 신청
Antony S / 1999 / Immunomodulatory activity of curcumin / Immunol Invest 28:291~303
Brownlee M / 2001 / Biochemistry and molecular cell biology of diabetic complications / Nature 414:813~820
차은정 / 2008 / 항산화 효소 활성에 대한 상황버섯추출물의 효과 / 대한암예방학회지 13(4):311~315
Dairam A / 2007 / Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats / J Agric Food Chem 55:1039~1044
Fontana M / 2001 / Interaction of enkephalins with oxyradicals / Biochem Pharmacol 61:1253~1257
Brownlee M / 2001 / Biochemistry and molecular cell biology of diabetic complications / Nature 414:813~820
차은정 / 2008 / 항산화 효소 활성에 대한 상황버섯추출물의 효과 / 대한암예방학회지 13(4):311~315
Dairam A / 2007 / Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats / J Agric Food Chem 55:1039~1044
Fontana M / 2001 / Interaction of enkephalins with oxyradicals / Biochem Pharmacol 61:1253~1257
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