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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 169 - 179 (11page)
- DOI
- 10.7783/KJMCS.2023.31.3.169
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초록· 키워드
오류제보하기
Background: Atopic dermatitis is a chronic inflammatory skin disease caused by skin barrier dysfunction. Allium victorialis var. platyphyllum (AVP) is a perennial plant considered as a vegetable and herbal medicine. This study aimed to investigate the effects of AVP on skin barrier and inflammatory response and indicate its potential as a new cosmetic materials
Methods and Results: High peformance liquid chromatography-ultraviolet analysis showed that AVP contains 0.12 ± 0.02 and 0.10 ± 0.01 ㎎/g of chlorogenic and gallic acids, respectively. AVP at 100 ㎍/㎖ was shown to increase the mRNA levels of filaggrin and involucrin, which are related to skin barrier function, by 1.50-fold and 1.43-fold, respectively. Based on a scratch assay, AVP at concentrations of 100 ㎍/㎖ and 200 ㎍/㎖ significantly increased wound closure rate and narrowed scratch area. AVP suppressed inflammation-related factors, such as cyclooxygenase 2 and nitric oxide, that were increased by lipopolysaccharide treatment. Additionally, AVP decreased the release of β-hexosaminidase which was increased by dinitrophenyl-bovine serum albumin treatment on RBL-2H3 cells.
Conclusions: Therefore, AVP can be developed as a functional cosmetic material for atopy management given its skin barrier protective, anti-inflammatory, and anti-pruritic effects.
Methods and Results: High peformance liquid chromatography-ultraviolet analysis showed that AVP contains 0.12 ± 0.02 and 0.10 ± 0.01 ㎎/g of chlorogenic and gallic acids, respectively. AVP at 100 ㎍/㎖ was shown to increase the mRNA levels of filaggrin and involucrin, which are related to skin barrier function, by 1.50-fold and 1.43-fold, respectively. Based on a scratch assay, AVP at concentrations of 100 ㎍/㎖ and 200 ㎍/㎖ significantly increased wound closure rate and narrowed scratch area. AVP suppressed inflammation-related factors, such as cyclooxygenase 2 and nitric oxide, that were increased by lipopolysaccharide treatment. Additionally, AVP decreased the release of β-hexosaminidase which was increased by dinitrophenyl-bovine serum albumin treatment on RBL-2H3 cells.
Conclusions: Therefore, AVP can be developed as a functional cosmetic material for atopy management given its skin barrier protective, anti-inflammatory, and anti-pruritic effects.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
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