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논문 기본 정보

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학술저널
저자정보
이영기 (한림대학교) Park Hayne Cho (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Republic of Korea.Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea.) 윤수진 (Department of Internal Medicine, Good Samaritan Bagae Hospital, Pyeongtaek, Republic of Korea) Sungbong Yu (Department of General Surgery, Good Samaritan Bagae Hospital, Pyeongtaek, Republic of Korea) 고은실 (National Emergency Medical Center, National Medical Center, Seoul, Republic of Korea) 조아진 (한림대학교) 김도형 (한림대학교) 김진석 (동국대학교) 기연경 (한림대학교 강동성심병원)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.43 No.1
발행연도
2024.1
수록면
111 - 121 (11page)
DOI
10.23876/j.krcp.23.137

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Background: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (COVID-19), there are lack of effective and proven treatments for end-stage renal disease (ESRD). The present study aims to evaluate the effectiveness of regdanvimab on mortality in COVID-19–infected patients on hemodialysis (HD).Methods: We conducted an observational retrospective study in 230 COVID-19–infected patients on HD, of whom 77 (33.5%) were administered regdanvimab alone or in combination with dexamethasone or remdesivir during hospitalization (regdanvimab group) and 153 patients (66.5%) were not (no regdanvimab group). The primary outcome was in-hospital mortality. We compared mortality rates according to the use of regdanvimab and investigated the factors associated with mortality. Results: Fifty-nine deaths occurred during hospitalization, 49 in the no regdanvimab group (32.0%) and 10 in the regdanvimab group (13.0%), and the mortality rate was significantly higher in the no regdanvimab group than that in the regdanvimab group (p = 0.001). Multivariate Cox regression analysis showed that malignancy (p = 0.001), SPO2 of <95% at admission (p = 0.003), and administration of antibiotics and regdanvimab (p = 0.007 and p = 0.002, respectively) were significantly associated factors with mortality.Conclusion: Regdanvimab administration is beneficial in improving prognosis in hospitalized COVID-19 patients on HD. Considering the vulnerability to infection and high mortality of ESRD patients, regdanvimab may be considered as a therapeutic option in COVID-19 patients on HD.

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