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논문 기본 정보

자료유형
학술저널
저자정보
Lim Chin Peng (School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia.Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Gelugor, Malaysia.) Leow Chiuan Herng (Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Gelugor, Malaysia.) Lim Hui Ting (Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Gelugor, Malaysia.) Kok Boon Hui (Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Gelugor, Malaysia.) Chuah Candy (Faculty of Medicine, Asian Institute of Medical Science and Technology University, Bedong, Malaysia.) Oliveira Jonas Ivan Nobre (Department of Biophysics and Pharmacology, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil.) Jones Malcolm (School of Veterinary Science, The University of Queensland, Gatton, Australia.) Leow Chiuan Yee (School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia.)
저널정보
대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.13 No.3
발행연도
2024.7
수록면
202 - 217 (16page)
DOI
10.7774/cevr.2024.13.3.202

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Structural vaccinology is pivotal in expediting vaccine design through high-throughput screen ing of immunogenic antigens. Leveraging the structural and functional characteristics of antigens and immune cell receptors, this approach employs protein structural comparison to identify conserved patterns in key pathogenic components. Molecular modeling techniques, including homology modeling and molecular docking, analyze specific three-dimensional (3D) structures and protein interactions and offer valuable insights into the 3D interactions and binding affinity between vaccine candidates and target proteins. In this review, we delve into the utilization of various immunoinformatics and molecular modeling tools to streamline the development of broad-protective vaccines against coronavirus disease 2019 variants. Struc tural vaccinology significantly enhances our understanding of molecular interactions between hosts and pathogens. By accelerating the pace of developing effective and targeted vaccines, particularly against the rapidly mutating severe acute respiratory syndrome coronavirus 2 and other prevalent infectious diseases, this approach stands at the forefront of advancing immunization strategies. The combination of computational techniques and structural insights not only facilitates the identification of potential vaccine candidates but also contributes to the rational design of vaccines, fostering a more efficient and targeted approach to combatting infectious diseases.

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