지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.3 No.4
- 발행연도
- 1998.12
- 수록면
- 315 - 319 (5page)
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초록· 키워드
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Previously, the methanolic extract of Paeonia moutan seeds was found to potently inhibit soybean lipoxygenase (SLO). Hence to isolate SLO inhibitor, the defatted methanolic extract of the seeds was consecutively partitioned with ether, ethyl acetate, n-butanol, and water. The ether souble fraction showing strong inhibitory activity against SLO was further fractionated into a strongly acidic, a weakly acidic, and a neutral fractions. The strongly acidic components of the ether extract were successively subjected to chromatography on a silica gel, Sephadex LH-20, and preparative HPLC. Four phenolic compounds were isolated, and two of them showing a strong SLO inhibition activity were identified as luteolin (IC_(50)=2.32 ㎍/ml) and 5,6,4'-trihydroxy-7,3'-dimethoxyflavone (IC_(50)=0.31 ㎍/ml) by UV, IR, ¹H- & ¹³C-NMR, and MS spectroscopy. In addition, two flavonoids showed significantly anti oxidative activity as strong as that of α-tocopherol (p<0.05) in the autoxidation system of linoleic acid. These results suggest that luteolin and 5,6,4'-trihydroxy-7,3'-dimethoxy-flavone may be used as a potential source of anti-inflammatory agents with antioxidative activity.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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