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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 119 - 123 (5page)
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Ginseng panaxadiol (PD) derivatives have been reported to retain anti-diabetic effect. Diabetic retinopathy is one of major complications of diabetes mellitus, which is induced by cell apoptosis of retina. Thus, this study was conducted to examine the protective effect of ginsenoside Rb2, a major component of PD derivatives, in the high glucose-induced cell loss of ARPE cells (a human retina pigment epithelial cell-line). In present study, high glucose induced the decrease of cell viability, which was blocked by the treatment of ginsenoside Rb2 (＞10<SUP>-6</SUP> g/㎖). In addition, high glucose increased the expression of Bax and decreased the expression of Bcl-2 expression, which was prevented by the treatment of ginsenoside Rb2. Furthermore, high glucose increased lipid peroxide formation and cyclooxygenase-2 (COX-2) expression, which was also blocked by the treatment of ginsenoside Rb2. In conclusion, ginsenoside Rb2 prevented high glucose-induced apoptosis via the decrease of lipid peroxide (LPO) and COX-2 expression in ARPE cells.
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감사의 글
참고문헌
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Abu El-Asrar, A.M / 2007 / Expression of antiapoptotic and proapoptotic molecules in diabetic retinas / Eye 21 : 238 ~ 245
2. [학술지(정기간행물)] - Ayalasomayajula, S.P / 2004 / Ayalasomayajula, S.P., Amrite, A.C. and Kompella, U.B. (2004) Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas / Eur. J. Pharmacol 498 : 275 ~ 278
3. [학술지(정기간행물)] - Bradford, M.M / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 : 248 ~ 254
4. [학술지(정기간행물)] - Cai, J / 2000 / Oxidative damage and protection of the RPE / Prog Retin. Eye. Res 19 : 205 ~ 221
5. [학술지(정기간행물)] - Cai, J / 1999 / Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells. Invest / Ophthalmol. Vis. Sci 40 : 959 ~ 966
2. [학술지(정기간행물)] - Ayalasomayajula, S.P / 2004 / Ayalasomayajula, S.P., Amrite, A.C. and Kompella, U.B. (2004) Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas / Eur. J. Pharmacol 498 : 275 ~ 278
3. [학술지(정기간행물)] - Bradford, M.M / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 : 248 ~ 254
4. [학술지(정기간행물)] - Cai, J / 2000 / Oxidative damage and protection of the RPE / Prog Retin. Eye. Res 19 : 205 ~ 221
5. [학술지(정기간행물)] - Cai, J / 1999 / Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells. Invest / Ophthalmol. Vis. Sci 40 : 959 ~ 966
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