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논문 기본 정보

자료유형
학술저널
저자정보
김영애 (경희대학교) 송은화 (경희대학교) 신경오 (충북대학교) 이용문 (충북대학교) 조윤희 (경희대학교)
저널정보
한국영양학회 한국영양학회지 한국영양학회지 제45권 제2호
발행연도
2012.4
수록면
113 - 120 (8page)

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In our previous studies, dietary supplements of silk protein, sericin, and fibroin, were beneficial for improving epidermal levels of ceramides, which are the major lipids for maintaining the epidermal barrier. In this study, we investigated the dietary effects of silk protein on epidermal levels of free sphingoid bases and their phosphates such as C<sub>18</sub> sphingosine (So), C<sub>18</sub> sphinganine (Sa), C<sub>18</sub> sphingosine-1-phosphate (S1P), and C<sub>18</sub> sphinganine-1-phosphate (Sa1P), which are either synthetic substrate or degradative metabolites of ceramides. Forty-five male NC/Nga mice, an animal model of atopic dermatitis (AD), were divided into three groups: group CA was an atopic control and fed a control diet, group S was fed a 1% sericin diet, and group F was fed a 1% fibroin diet. Fifteen male BALB/c mice served as group C (control group) and were fed the control diet. All mice were fed with diets and water ad libitum for 10 weeks. Sa in group CA was lower than that in group C, but So in group CA was similar to that in group C. So and Sa were higher in groups S and F than those in group CA; So level was even higher than that in group C, and Sa level was similar to that of group C. The So/Sa ratio in group CA, which is reported to increase in AD, was significantly higher than that of group C. The So/Sa ratio was lower in groups S and F than that in group CA, and decreased further in group F. However, S1P and Sa1P in groups S and F were similar to those in group CA. Taken together, we demonstrated that silk protein, sericin and fibroin dietary supplements, increased So and Sa levels, and decreased the So/Sa ratio. (Korean J Nutr 2012; 45(2): 113 ~ 120)

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