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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 194 - 201 (8page)
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이 논문의 연구 히스토리 (2)
2019
Comparison of Anti-oxidant and Anti-inflammatory Activities of Methanolic Extracts Obtained from Different Parts of Cotoneaster wilsonii Nakai
Nam Ho Yoo
,
Hee Kyu Kim
,
Chan Ok Lee
외 3명
한국약용작물학회지
2019.06
학술저널
Comparison of Biological Activities of Methanol Extracts Different Parts of Cotoneaster wilsonii Nakai
Nam Ho Yoo
,
Byung Jun Pa
,
k
외 4명
한국약용작물학회 학술대회논문집
2019.05
학술대회자료
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Background: The Ministry of Environment, Korea recognizes Cotoneaster wilsonii Nakai as a second-class endangered plant. It is a native species that grows in Ulleung-do, Korea. To our knowledge, the bioactivity of this plant has not yet been reported. Therefore, in this study, we have reported the bioactivity of C. wilsonii Nakai.
Methods and Results: The anti-oxidant activities of C. wilsonii methanolic extract were investigated in vitro. The anti-oxidant activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay, and the total phenolic and flavonoid content were measured. The leaf methanolic extract had the highest DPPH radical scavenging activity (IC50; 15.74 ㎍/㎖), and it also had the highest total phenolic and flavonoid content (220.95 ㎎·GAE/g, and 36.46 ㎎·QE/g extract respectively). Through high performance liquid chromatography (HPLC) analysis, chlorogenic acid was found to be the predominant among all phenolic compounds, showing a concentration of 84.24 ㎎/g extract. More than 60% decrease in nitric oxide (NO) production was found in the leaf methanolic extract.
Conclusions: To the best of our knowldege, this is the first report of the bioactivities of C. wilsonii. The results demonstrate that the leaf methanolic extract of C. wilsonii shows potent anti-oxidant, and anti-inflammatory activities.
Methods and Results: The anti-oxidant activities of C. wilsonii methanolic extract were investigated in vitro. The anti-oxidant activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay, and the total phenolic and flavonoid content were measured. The leaf methanolic extract had the highest DPPH radical scavenging activity (IC50; 15.74 ㎍/㎖), and it also had the highest total phenolic and flavonoid content (220.95 ㎎·GAE/g, and 36.46 ㎎·QE/g extract respectively). Through high performance liquid chromatography (HPLC) analysis, chlorogenic acid was found to be the predominant among all phenolic compounds, showing a concentration of 84.24 ㎎/g extract. More than 60% decrease in nitric oxide (NO) production was found in the leaf methanolic extract.
Conclusions: To the best of our knowldege, this is the first report of the bioactivities of C. wilsonii. The results demonstrate that the leaf methanolic extract of C. wilsonii shows potent anti-oxidant, and anti-inflammatory activities.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Bauer G. / 2000 / Reactive oxygen and nitrogen species: Efficient, selective, and interactive signals during intercellular induction of apoptosis / Anticancer Research 20:4115~4139
Blois MS. / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181:1199~1200
Chang CS / 2003 / Leaf flavonoids in Cotoneaster wilsonii(Rosaceae) from the island Ulleung-do, Korea / Biochemical Systematics and Ecology 31:171~179
Chung HY / 2009 / Molecular inflammation: Underpinnings of aging and age-related diseases / Ageing Research Reviews 8:18~30
Yishan Duan / 2015 / Antioxidant Activities of n-Butanol and Ethyl Acetate Extracts from Yam (Dioscorea batatas DECNE.) / 한국응용과학기술학회지 32(4):599~606
Blois MS. / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181:1199~1200
Chang CS / 2003 / Leaf flavonoids in Cotoneaster wilsonii(Rosaceae) from the island Ulleung-do, Korea / Biochemical Systematics and Ecology 31:171~179
Chung HY / 2009 / Molecular inflammation: Underpinnings of aging and age-related diseases / Ageing Research Reviews 8:18~30
Yishan Duan / 2015 / Antioxidant Activities of n-Butanol and Ethyl Acetate Extracts from Yam (Dioscorea batatas DECNE.) / 한국응용과학기술학회지 32(4):599~606
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UCI(KEPA) : I410-ECN-0101-2019-480-000930973