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Background and Purpose Epilepsy is a chronic neurological disease that represents a tremendousburden on both patients and society in general. Studies have addressed how demographicvariables, socioeconomic variables, and psychological comorbidity are related to thequality of life (QOL) of people with epilepsy (PWE). However, there has been less focus on howthese factors may differ between patients who exhibit varying degrees of seizure control. Thisstudy utilized data from the Managing Epilepsy Well (MEW) Network of the Centers for DiseaseControl and Prevention with the aim of elucidating differences in demographic variables,depression, and QOL between adult PWE. Methods Demographic variables, depression, and QOL were compared between PWE whoexperience clinically relevant differences in seizure occurrence. Results Gender, ethnicity, race, education, income, and relationship status did not differ significantlybetween the seizure-frequency categories (p>0.05). People with worse seizure controlwere significantly younger (p=0.039), more depressed (as assessed using the Patient HealthQuestionnaire) (p=0.036), and had lower QOL (as determined using the 10-item Quality of Lifein Epilepsy for Adults scale) (p<0.001). Conclusions The present results underscore the importance of early screening, detection, andtreatment of depression, since these factors relate to both seizure occurrence and QOL in PWE.

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