지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Bisphenol A diglycidyl ether (BADGE) is a liquid compound obtained by condensation of two molecules of epichlorohydrin with one molecule of bisphenol A. General and reproductive toxicity with BADGE has been reported higher than 1000 mg/kg/day. This study was performed to show the effects of acute exposure to BADGE below 1000mg/kg/day on the testis in adult male rats.
Methods: BADGE was administered by gastric lavage in a single dose of 500, 750, 1000, and 2000 mg/kg/day in 8-week old male SPF Sprague-Dawley rats. The right testis was processed for light microscopic analysis. The left testis was homogenized and spermatids were counted to determine the daily sperm production and daily abnormal sperm production. The sperm count, sperm motility, and incidence of abnormal sperm were estimated in the epididymis. In testicular sections, the seminiferous tubules were observed for qualitative changes. The progression of spermatogenesis was arbitrarily classified as full-matured, maturing, and immature. The specimen slide was observed at 3 points and 10seminiferous tubules were evaluated at each point.
Results: The male rats exposed to single oral dose of BADGE at 750, 1000, and 2000 mg/kg/day were significantly increased the number of immature and maturing sperm on the testis. There were no significant differences with respect to sperm head count, sperm motility, and sperm abnormality in the BADGE treatment groups.
Conclusions: These results suggest that single oral exposure of BADGE 750 mg/kg/day can affect adult male testis development.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Brotons JA / 1995 / Xenoestrogens released from lacquer coatings in food cans / Environ Health Perspect 103 (6) : 608 ~ 612
Cassidy SL / 1983 / Evaluation of a testicular sperm head counting technique using rats exposed to dimethoxy-ethyl phthalate (DMEP), glycerol amonochlorohydrin (GMCH), epich
Hammarling L / 2000 / Migration of bisphenol A diglycidyl ether (BADGE) and its reaction products in canned foods / Food Addit Contam 17 (1) : 937 ~ 943
Hine CH / 1958 / The toxicology of epoxy resins / AMA Arch Ind Health 17 (2) : 129 ~ 144
International Agency for Research on Cancer (IARC) / 1999 / Reevaluation of some organic chemicals, hydrazine and hydrogen peroxide / IARC Monogr Eval Carcinog Risks Hum 71 (
Cassidy SL / 1983 / Evaluation of a testicular sperm head counting technique using rats exposed to dimethoxy-ethyl phthalate (DMEP), glycerol amonochlorohydrin (GMCH), epich
Hammarling L / 2000 / Migration of bisphenol A diglycidyl ether (BADGE) and its reaction products in canned foods / Food Addit Contam 17 (1) : 937 ~ 943
Hine CH / 1958 / The toxicology of epoxy resins / AMA Arch Ind Health 17 (2) : 129 ~ 144
International Agency for Research on Cancer (IARC) / 1999 / Reevaluation of some organic chemicals, hydrazine and hydrogen peroxide / IARC Monogr Eval Carcinog Risks Hum 71 (
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