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Epilepsy is a chronic neurological disease which produces repeated seizures. Over 30% of epileptic patients cannot be treated with anti-epileptic drugs, and surgical resection may cause loss of brain functions. Seizure suppression by electrical stimulation is currently being investigated as a new treatment method as clinical evidence has shown that electrical stimulation to brain could suppress seizure activity. In this paper, design of a real-time closed-loop neurostimulation system for epileptic seizure suppression is presented. The system records neural signals, detects seizures and delivers electrical stimulation. The system consists of a 6-channel electrode, front-end amplifiers, a data acquisition board by National Instruments, and a neurostimulator and Generic Osorio-Frei algorithm was applied for seizure detection. The algorithm was verified through simulation using electroencephalogram data, and the operation of whole system was verified through simulation and in- vivo test.
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참고문헌 (12)
참고문헌 신청
C. C. Jouny / 2012 / Characterization of Early Partial Seizure Onset: Frequency, Complexity and Entropy / Clin. Neurophysiol 123 : 658 ~ 669
C. Y. Wu / 2013 / A CMOS Power-Efcient Low-Noise Current-Mode Front-End Amplier for Neural Signal Recording / IEEE Trans. Biomed. Circuits Syst. 7 (2) : 107 ~ 114
H. Miranda / 2010 / HermesD: A High-Rate Long-Range Wireless Transmission System for Simultaneous Multichannel Neural Recording Applications / IEEE Trans. Biomed. Circuits S
I. Osorio / 1998 / Real-Time Automated Detection and Quantitative Analysis of Seizures and Short-Term Prediction of Clinical Onset / Epilepsia 39 (6) : 615 ~ 627
L. Liu / 2013 / Neural Recording Front-End IC Using Action Potential Detection and Analog Buffer with Digital Delay for Data Compression / 35th Annual International Conference of
C. Y. Wu / 2013 / A CMOS Power-Efcient Low-Noise Current-Mode Front-End Amplier for Neural Signal Recording / IEEE Trans. Biomed. Circuits Syst. 7 (2) : 107 ~ 114
H. Miranda / 2010 / HermesD: A High-Rate Long-Range Wireless Transmission System for Simultaneous Multichannel Neural Recording Applications / IEEE Trans. Biomed. Circuits S
I. Osorio / 1998 / Real-Time Automated Detection and Quantitative Analysis of Seizures and Short-Term Prediction of Clinical Onset / Epilepsia 39 (6) : 615 ~ 627
L. Liu / 2013 / Neural Recording Front-End IC Using Action Potential Detection and Analog Buffer with Digital Delay for Data Compression / 35th Annual International Conference of
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