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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 11 - 32 (22page)
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초록· 키워드
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Objective : This study was designed to investigate anti-cancer and whitening activities of Lonicerae Caulis
(LC). So it was investigated the effects of LC on proliferation rates of melanoma cells, then effects on
genetic profile by LC.
Methods : The genetic profile for the effect of LC on human derived melanoma cell, SK-MEL-2, was
measured using microarray technique, and the functional analysis on these genes were conducted. Total 441
genes were up-regulated and 830 genes down-regulated in cells treated with LC. Genes induced or
suppressed by LC were all mainly concerned with basic signalling pathways, which are involved in cell
growth, differentiation and migration. Especially, many genes, which are related in apoptosis and cell cycle
arrest were up-regulated by treatment with LC, and genes related in cell cycle were down-regulated.
Result : The network of total protein interactions were identified by using cytoscape program, and some
key molecules, such as BCL2L1, SIN3A, SMAD2 and c-myc that can be used for elucidation of therapeutical
mechanism of medicine in the future.
Conclusion : These results suggest possibility of LC as anti-cancer drug and whitening cosmetics. In
addition, it was also suggested that related mechanisms are involved in BCL2L1, SIN3A, SMAD2 and c-myc
related signalling pathways.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Blanchard AP / 1996 / High-density oligonucleotide arrays / Biosensors Bioelectron 11 : 687 ~ 690
Choi HJ / 2006 / Petrotetrayndiol A induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells through cytochrome c-mediated activation of caspases / Cancer Le
Florell SR / 2001 / Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol / Mod Pathol 14 (2) : 116 ~ 128
Kang OH / 2004 / Inhibition of trypsin-induced mast cell activation by water fraction of Lonicera japonica / Arch Pharm Res 27 (11) : 1141 ~ 1146
Kim JA / 2005 / Inhibitory effect of luteolin on TNF-αlpha-induced IL-8 production in human colon epithelial cells / Int Immunopharmacol 5 (1) : 209 ~ 217
Choi HJ / 2006 / Petrotetrayndiol A induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells through cytochrome c-mediated activation of caspases / Cancer Le
Florell SR / 2001 / Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol / Mod Pathol 14 (2) : 116 ~ 128
Kang OH / 2004 / Inhibition of trypsin-induced mast cell activation by water fraction of Lonicera japonica / Arch Pharm Res 27 (11) : 1141 ~ 1146
Kim JA / 2005 / Inhibitory effect of luteolin on TNF-αlpha-induced IL-8 production in human colon epithelial cells / Int Immunopharmacol 5 (1) : 209 ~ 217
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