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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 55 - 62 (8page)
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초록· 키워드
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Elevated expression of protein casein kinase II (CKII)
stimulated basal phospholipase D (PLD) activity as
well as PMA-induced PLD activation in human U87
astroglioma cells. Moreover, CKII-selective inhibi-tor,
emodin and apigenin suppressed PMA-induced
PLD activation in a dose-dependent manner as well
as basal PLD activity, suggesting the involvement of
CKII in the activation of both PLD1 and PLD2. CKII was
associated with PLD1 and PLD2 in co-transfection
experiments. Furthermore, CKII induced serine/thre -onine
phosphorylation of PLD2 in vivo, and the
multiple regions of PLD2 were phosphorylated by
CKII in vitro kinase assay using glutathione S-trans -ferase-
PLD2 fusion protein fragments. Elevated
expression of CKII or PLD increased cell proliferation
but pretreatment of cells with 1-butanol suppressed
CKII-induced cell proliferation. These results sug -gest
that CKII is involved in proliferation of U87 cells
at least in part, through stimulation of PLD activity.
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참고문헌 (29)
참고문헌 신청
/ / Activation of a tumor- associated protein kinase and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung : 2262 ~ 8
/ / Purification and characterization of echinoderm casein kinase II Re-gulation of protein kinase C : 829 ~ 37
/ / Significance of the casein kinase system in cell growth and proliferation with emphasis on studies of the androgenic regulation of the prostate : 1 ~ 11
/ / an eminence gris in celular regulation? Biochimica et Biophysica Acta 1990;1054 : 267 ~ 84
/ 190-6 / Phosphoserine in peptide substrates can specify casein kinase II action
/ / Purification and characterization of echinoderm casein kinase II Re-gulation of protein kinase C : 829 ~ 37
/ / Significance of the casein kinase system in cell growth and proliferation with emphasis on studies of the androgenic regulation of the prostate : 1 ~ 11
/ / an eminence gris in celular regulation? Biochimica et Biophysica Acta 1990;1054 : 267 ~ 84
/ 190-6 / Phosphoserine in peptide substrates can specify casein kinase II action
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