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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 456 - 464 (9page)
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As glucose is known to induce insulin secretion in pancreatic β cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high glucose in the pancreatic β-cell line MIN6N8. It was found that the PLD activity and PLD1 expression were both increased by high glucose (33.3 mM) treatment. The dominant negative PLD1 inhibited glucose-induced Beta2 expression,and glucose-induced insulin secretion was blocked by treatment with 1-butanol or PLD1-siRNA. These results suggest that high glucose increased insulin secretion through a PLD1-related pathway. High glucose induced the binding of Arf6 to PLD1. Pretreatment with brefeldin A (BFA), an Arf inhibitor, decreased the PLD activity as well as the insulin secretion. Furthermore,BFA blocked the glucose-induced mTOR and p70S6K activation, while mTOR inhibition with rapamycin attenuated the glucose induced Beta2 expression and insulin secretion. Thus, when taken together, PLD1would appear to be an important regulator of glucose-induced insulin secretion through an Arf6/PLD1/mTOR/p70S6K/ Beta2 pathway in MIN6N8cells.
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참고문헌 (23)
참고문헌 신청
Andrali SS / 2008 / Glucose regulation of insulin gene expression in pancreatic β-cells / Biochem J 415 : 1 ~ 10
Aramata S / 2005 / Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1 / Biochim Biophy Acta 1730 : 41 ~
Ashcroft SJ / 1980 / Glucoreceptor mechanisms and the control of insulin release and biosynthesis / Diabetologia 18 : 5 ~ 15
Bligh EG / 1959 / A rapid method of total lipid extraction and purification / Can J Biochem Physiol 37 : 911 ~ 917
Briaud I / 2003 / Differential activation mechanisms of Erk-1/2 and p70S6K by glucose in pancreatic β-cells / Diabetes 52 : 974 ~ 983
Aramata S / 2005 / Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1 / Biochim Biophy Acta 1730 : 41 ~
Ashcroft SJ / 1980 / Glucoreceptor mechanisms and the control of insulin release and biosynthesis / Diabetologia 18 : 5 ~ 15
Bligh EG / 1959 / A rapid method of total lipid extraction and purification / Can J Biochem Physiol 37 : 911 ~ 917
Briaud I / 2003 / Differential activation mechanisms of Erk-1/2 and p70S6K by glucose in pancreatic β-cells / Diabetes 52 : 974 ~ 983
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