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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제12호
- 발행연도
- 2015.1
- 수록면
- 2,146 - 2,152 (7page)
이용수
초록· 키워드
오류제보하기
Apios americana Medik (hereinafter Apios) has been reported to treat diseases, including cancer, hypertension, obesity, and diabetes. The therapeutic effect of Apios is likely to be associated with its anti-inflammatory activity. This study was conducted to evaluate the protective effects of Apios in animal models of acute lung injury induced by lipopolysaccharide (LPS) or pandemic H1N1 2009 influenza A virus (H1N1). Mice were exposed to LPS or H1N1 for 2–4 days to induce acute lung injury. The treatment groups were administered Apios extracts via oral injection for 8 weeks before LPS treatment or H1N1 infection. To investigate the effects of Apios, we assessed the mice for in vivo effects of Apios on immune cell infiltration and the level of pro-inflammatory cytokines in the bronchoalveolar lavage (BAL) fluid, and histopathological changes in the lung. After induction of acute lung injury, the numbers of neutrophils and total cells were lower in the Apios-treated groups than in the non-Apios-treated LPS and H1N1 groups. The Apios groups tended to have lower levels of tumor necrosis factor-a and interleukin-6 in BAL fluid. In addition, the histopathological changes in the lungs were markedly reduced in the Apios-treated groups. These data suggest that Apios treatment reduces LPS- and H1N1-induced lung inflammation. These protective effects of Apios suggest that it may have therapeutic potential in acute lung injury.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abraham E / 1999 / Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation / Am. J. Physiol 276 : L1 ~ L8
Abraham E. / 2003 / Neutrophils and acute lung injury / Crit. Care Med 31 : S195 ~ S199
Atteritano M / 2007 / Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, doubleblind
Crowe CR / 2009 / Critical role of IL-17RA in immunopathology of influenza infection / J. Immunol 183 : 5301 ~ 5310
Duan GJ / 2010 / A synthetic MD-2 mimetic peptide attenuates lipopolysaccharide-induced inflammatory responses in vivo and in vitro / Int. Immunopharmacol 10 : 1091 ~ 1100
Abraham E. / 2003 / Neutrophils and acute lung injury / Crit. Care Med 31 : S195 ~ S199
Atteritano M / 2007 / Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, doubleblind
Crowe CR / 2009 / Critical role of IL-17RA in immunopathology of influenza infection / J. Immunol 183 : 5301 ~ 5310
Duan GJ / 2010 / A synthetic MD-2 mimetic peptide attenuates lipopolysaccharide-induced inflammatory responses in vivo and in vitro / Int. Immunopharmacol 10 : 1091 ~ 1100
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