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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 225 - 231 (7page)
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초록· 키워드
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Objectives: The purpose of this study was to investigate the demographic and clinical characteristics of patients with medication-related osteonecrosis of the jaw (MRONJ) and to elucidate factors affecting recurrence in surgical treatment. Materials and Methods: A total of 51 patients who were diagnosed with MRONJ were analyzed according to demographic and clinical features and treatment results through a retrospective chart review from 2013 to 2017 in the Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, Seoul in Korea. Results: Alendronate composed the majority of medication doses (55.6%), followed by ibandronate (20.0%), risedronate (15.6%), and zoledronate (6.7%). Forty patients (88.9%) were given oral medication, and five patients (11.1%) were intravenously treated, and the mean duration of medication use was 61.1±42.9 months. A total of 10 patients (22.2%) had a drug holiday before MRONJ-induced dental treatment lasting an average of 6.8±7.0 months. MRONJ occurred 2.7 times more in the mandible, with 41 cases (73.2%) occurring in the mandible and 15 cases (26.8%) occurring in the maxilla, and the prevalence of affected posterior parts (premolar-molar) was six times greater than that of the anterior parts (incisor-canine) (48 cases vs 8 cases, 85.7% vs 14.3%). The most common dental cause of MRONJ was tooth extraction (69.6%). Regarding recurrence, there was no statistical difference in recurrence rate according to either site or stage. However, recurrence occurred in 4 out of 34 cases (11.8%) in the primary closure group and 9 out of 20 cases (45.0%) in the secondary healing group, and there was a statistical difference with respect to closure technique. Conclusion: The identified risk factors in patients taking bone resorption inhibitors can aid dental clinicians in ensuring prevention and proper treatment of MRONJ.
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참고문헌 (7)
참고문헌 신청
김경민 / 2015 / Medication Related Osteonecrosis of the Jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons / 대한골대사학회지 22(4):151~165
Hyo Won Jang / 2015 / Development of animal model for Bisphosphonates-related osteonecrosis of the jaw (BRONJ) / Maxillofacial Plastic Reconstructive Surgery 37(7):1~7
Hong-Joon Kim / 2016 / Bisphosphonate-related osteonecrosis of the jaw in metastatic breast cancer patients: a review of 25 cases / Maxillofacial Plastic Reconstructive Surgery 38(2):1~8
최우성 / 2017 / Medication-related osteonecrosis of the jaw: a preliminary retrospective study of 130 patients with multiple myeloma / Maxillofacial Plastic Reconstructive Surgery 39(1):1~7
이호경 / 2013 / 비스포스포네이트 관련 악골괴사(BRONJ)의 병기 2기에서의 외과적, 보존적 치료에 대한 비교 연구 / Maxillofacial Plastic Reconstructive Surgery 35(5):302~309
Hyo Won Jang / 2015 / Development of animal model for Bisphosphonates-related osteonecrosis of the jaw (BRONJ) / Maxillofacial Plastic Reconstructive Surgery 37(7):1~7
Hong-Joon Kim / 2016 / Bisphosphonate-related osteonecrosis of the jaw in metastatic breast cancer patients: a review of 25 cases / Maxillofacial Plastic Reconstructive Surgery 38(2):1~8
최우성 / 2017 / Medication-related osteonecrosis of the jaw: a preliminary retrospective study of 130 patients with multiple myeloma / Maxillofacial Plastic Reconstructive Surgery 39(1):1~7
이호경 / 2013 / 비스포스포네이트 관련 악골괴사(BRONJ)의 병기 2기에서의 외과적, 보존적 치료에 대한 비교 연구 / Maxillofacial Plastic Reconstructive Surgery 35(5):302~309
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