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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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An extract of Allomyrina dichotoma larva (ADL), one of the insects used most frequently
in traditional Chinese medicine for the treatment of liver diseases such as hepatocirrhosis and
hepatofibrosis, was assessed for antioxidant bioactivity in this study. In the current work, we have
investigated the protective effects of ADL extracts on tert-butyl hydroperoxide (t-BHP)-induced
hepatotoxicity in cultured hepa1c1c7 cells and in the mouse liver. The treatment of the hepa1c1c7
cells with ADL extracts induced a significant reduction of t-BHP-induced oxidative injuries, as
determined by cell cytotoxicity, lipid peroxidation (LPO) and reactive oxygen species contents, in
a dose-dependent manner. Moreover, ADL extracts evidenced a protective effect against t-BHPinduced
oxidative DNA damage, as revealed by the results of the Comet assay in hepa1c1c7 cells.
ADL extracts also protected against hydroxyl radical-induced 2-deoxy-d-ribose degradation by
ferric ion-nitrilotriacetic acid and H2O2. In addition, ADL extracts were shown to be able to quench
1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. Our in vivo study revealed that ADL extracts
pretreatment applied prior to t-BHP administration significantly prevented an increase in the serum
levels of hepatic enzyme markers and reduced LPO in the mouse liver in a dose-dependent
manner. Taken together, these results suggest that the protective effects of ADL extracts against t-
BHP-induced hepatotoxicity may be attributable, at least in part, to its ability to scavenge free oxygen
radicals, and to protect against DNA damage due to oxidative stress.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Blair IA / 2001 / Lipid hydroperoxide-mediated DNA damage / Exp. Gerontol. 36 : 1473 ~ 1481
Fruehauf JP / 2007 / Reactive oxygen species: a breath of life or death? / Clin. Cancer Res. 13 : 789 ~ 794
Goya L / 2007 / Effect of coffee melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide / Mol. Nutr. Food Res. 51 :
Jenner P / 1998 / Understanding cell death in Parkinson’s disease / Annals of neurology 44 : S72 ~ 84
Johnson MK / 2000 / Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA / Mutat. Res. 459 : 211 ~ 218
Fruehauf JP / 2007 / Reactive oxygen species: a breath of life or death? / Clin. Cancer Res. 13 : 789 ~ 794
Goya L / 2007 / Effect of coffee melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide / Mol. Nutr. Food Res. 51 :
Jenner P / 1998 / Understanding cell death in Parkinson’s disease / Annals of neurology 44 : S72 ~ 84
Johnson MK / 2000 / Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA / Mutat. Res. 459 : 211 ~ 218
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