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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 44 - 53 (10page)
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초록· 키워드
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Purpose: Up to now, there is no feasible solution for stopping or reversing the degenerative process of osteoarthritis (OA). Our study evaluated the effect of intraarticular injection of growth hormone (GH) in OAinduced rabbit knees compared to hyaluronic acid (HA) and placebo.Materials and Methods: A total of 21 male, skeletally mature, New Zealand rabbits received an intraarticular type II collagenase injection for OA induction. Two weeks later, the rabbits were randomized into three groups based on the weekly intraarticular injection to be received: GH, HA, and saline. Injections were done for three consecutive weeks. Evaluation was done at 8 weeks after treatment, clinically using the lameness period, macroscopically using the Yoshimi score and microscopically using the Mankin score. Results: The shortest period of lameness was found in the GH group (15.9±2.12 days), compared to the HA group (19.4±1.72 days) and placebo group (25.0±2.94 days). There was a statistically significant difference in macroscopic scoring between groups (p=0.001) in favor of the GH group. There was also significant difference in the microscopic score between groups (p=0.001) also in favor of the GH group.Conclusions: Intraarticular injection of GH showed better clinical, macroscopic and microscopic results as compared to HA and placebo.
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참고문헌 (27)
참고문헌 신청
Iijima H / 2014 / Destabilization of the medial meniscus leads to subchondral bone defects and sitespecific cartilage degeneration in an experimental rat model / Osteoarthritis Cartilage 22:1036~1043
Kuijt MT / 2012 / Knee and ankle osteoarthritis in former elite soccer players : a systematic review of the recent literature / J Sci Med Sport 15:480~487
Sagar DR / 2015 / Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat / Osteoarthritis Cartilage 23:906~913
Muramatsu Y / 2014 / Preventive effects of hyaluronan from deterioration of gait parameters in surgically induced mice osteoarthritic knee model / Osteoarthritis Cartilage 22:831~835
Fuchsjager-Mayrl G / 2002 / Exercise training improves vascular endothelial function in patients with type 1 diabetes / Diabetes Care 25:1795~1801
Kuijt MT / 2012 / Knee and ankle osteoarthritis in former elite soccer players : a systematic review of the recent literature / J Sci Med Sport 15:480~487
Sagar DR / 2015 / Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat / Osteoarthritis Cartilage 23:906~913
Muramatsu Y / 2014 / Preventive effects of hyaluronan from deterioration of gait parameters in surgically induced mice osteoarthritic knee model / Osteoarthritis Cartilage 22:831~835
Fuchsjager-Mayrl G / 2002 / Exercise training improves vascular endothelial function in patients with type 1 diabetes / Diabetes Care 25:1795~1801
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